Epileptogenesis

Epileptogenesis refers to the gradual process through which a previously non-epileptic brain undergoes pathological changes that ultimately lead to the development of epilepsy.[1][2] Epilepsy is a chronic neurological condition characterized by an enduring predisposition to generate epileptic seizures,[3] which are episodes of abnormal, hypersynchronous neuronal firing.[4][5]

It encompasses the transformation of neuronal networks following an initial insult, such as trauma, infection, or prolonged seizures, resulting in a brain capable of generating spontaneous recurrent seizures. This process is distinct from ictogenesis, which describes the immediate mechanisms underlying the initiation of individual seizure events. While ictogenesis accounts for seizure generation, epileptogenesis involves the long-term alterations that predispose the brain to recurrent seizures.[1]

  1. ^ a b Pitkänen, Asla; Engel, Jerome (2014-04-01). "Past and Present Definitions of Epileptogenesis and Its Biomarkers". Neurotherapeutics. 11 (2): 231–241. doi:10.1007/s13311-014-0257-2. ISSN 1878-7479. PMC 3996117. PMID 24492975.
  2. ^ Lukasiuk, K (2014). "Epileptogenesis". In Aminoff, Michael J; Daroff, Robert B (eds.). Encyclopedia of the Neurological Sciences. Vol. 2 (Second ed.). London: Academic Press. pp. 196–199. ISBN 978-0-12-385157-4.
  3. ^ McNamara, James O.; Huang, Yang Zhong; Leonard, A. Soren (2006-10-10). "Molecular Signaling Mechanisms Underlying Epileptogenesis". Science's STKE. 2006 (356): re12. doi:10.1126/stke.3562006re12. ISSN 1525-8882. PMID 17033045.
  4. ^ Fisher, Robert S.; Acevedo, Carlos; Arzimanoglou, Alexis; Bogacz, Alicia; Cross, J. Helen; Elger, Christian E.; Engel, Jerome; Forsgren, Lars; French, Jacqueline A.; Glynn, Mike; Hesdorffer, Dale C.; Lee, B.I.; Mathern, Gary W.; Moshé, Solomon L.; Perucca, Emilio (2014). "ILAE Official Report: A practical clinical definition of epilepsy". Epilepsia. 55 (4): 475–482. doi:10.1111/epi.12550. ISSN 0013-9580. PMID 24730690.
  5. ^ Armijo, J. A.; Valdizán, E. M.; De Las Cuevas, I.; Cuadrado, A. (2002-03-01). "[Advances in the physiopathology of epileptogenesis: molecular aspects]". Revista de Neurologia. 34 (5): 409–429. ISSN 0210-0010. PMID 12040510.
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