Erenumab

Erenumab
A standard 70mg/mL Aimovig autoinjector
Monoclonal antibody
TypeWhole antibody
SourceHuman
TargetCGRPR
Clinical data
Trade namesAimovig
Other namesAMG-334, erenumab-aooe
AHFS/Drugs.comMonograph
MedlinePlusa618029
License data
Pregnancy
category
Routes of
administration		Subcutaneous injection
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability82% (estimated)
MetabolismProteolysis
Elimination half-life28 days
Identifiers
CAS Number
DrugBank
ChemSpider
  • none
UNII
KEGG
ChEMBL
Chemical and physical data
FormulaC6472H9964N1728O2018S50
Molar mass145871.98 g·mol−1

Erenumab, sold under the brand name Aimovig, is a medication which blocks the calcitonin gene-related peptide receptor (CGRPR) for the prevention of migraine.[3][4][5] It is administered by subcutaneous injection.[3][4]

Erenumab, which was developed by Amgen and Novartis,[5] was approved in May 2018, and was the first CGRPR antagonist to be approved by the U.S. Food and Drug Administration.[6] In 2020, it was the 234th most commonly prescribed medication in the United States, with more than 1 million prescriptions.[7][8]

  1. ^ "Erenumab (Aimovig) Use During Pregnancy". Drugs.com. 17 April 2019. Archived from the original on 29 November 2020. Retrieved 5 May 2020.
  2. ^ "Summary Basis of Decision (SBD) for Aimovig". Health Canada. 23 October 2014. Archived from the original on 31 May 2022. Retrieved 29 May 2022.
  3. ^ a b c "Aimovig- erenumab-aooe injection Aimovig- erenumab-aooe injection, solution". DailyMed. 19 August 2022. Archived from the original on 5 July 2022. Retrieved 29 September 2022.
  4. ^ a b c Cite error: The named reference Aimovig EPAR was invoked but never defined (see the help page).
  5. ^ a b Goadsby PJ, Reuter U, Hallström Y, Broessner G, Bonner JH, Zhang F, et al. (November 2017). "A Controlled Trial of Erenumab for Episodic Migraine". The New England Journal of Medicine. 377 (22): 2123–2132. doi:10.1056/NEJMoa1705848. PMID 29171821.
  6. ^ Cite error: The named reference Medscape was invoked but never defined (see the help page).
  7. ^ "The Top 300 of 2020". ClinCalc. Retrieved 7 October 2022.
  8. ^ "Erenumab - Drug Usage Statistics". ClinCalc. Retrieved 7 October 2022.
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