Ewing family of tumors

The Ewing family of tumors (EFTs) is a group of small cell sarcomas including Ewing sarcoma of the bone, extra osseous Ewing tumors, and primitive neuroectodermal tumors. They are rare cancers, usually diagnosed in peoples' twenties. The sarcoma of bone is the most common of the variants. All forms are predisposed to metastasis and have had historically high rates of mortality. The family of tumors shares a common translocation mutation of the EWS gene on chromosome 22 to an ETS-type gene, most commonly the FLI1 gene.[1]  EFTs are highly malignant, with 5-year survival for patients with metastatic disease at 20%.  The current standard of care includes resection, radiation, and chemotherapy.[2]

  1. ^ Iwamoto Y (February 2007). "Diagnosis and treatment of Ewing's sarcoma". Japanese Journal of Clinical Oncology. 37 (2): 79–89. doi:10.1093/jjco/hyl142. PMID 17272319.
  2. ^ Yu H, Ge Y, Guo L, Huang L (January 2017). "Potential approaches to the treatment of Ewing's sarcoma". Oncotarget. 8 (3): 5523–5539. doi:10.18632/oncotarget.12566. PMC 5354928. PMID 27740934.
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