Expression quantitative trait loci

An expression quantitative trait locus (eQTL) is a type of quantitative trait locus (QTL), a genomic locus (region of DNA) that is associated with phenotypic variation for a specific, quantifiable trait. While the term QTL can refer to a wide range of phenotypic traits, the more specific eQTL refers to traits measured by gene expression, such as mRNA levels.[1][2] Although named "expression QTLs", not all measures of gene expression can be used for eQTLs. For example, traits quantified by protein levels are instead referred to as protein QTLs (pQTLs).

  1. ^ Rockman MV, Kruglyak L (November 2006). "Genetics of global gene expression". Nature Reviews. Genetics. 7 (11): 862–72. doi:10.1038/nrg1964. PMID 17047685. S2CID 150368.
  2. ^ Nica, Alexandra C.; Dermitzakis, Emmanouil T. (2013). "Expression quantitative trait loci: Present and future". Philosophical Transactions of the Royal Society B: Biological Sciences. 368 (1620): 20120362. doi:10.1098/rstb.2012.0362. PMC 3682727. PMID 23650636.
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