Famotidine

Famotidine
Clinical data
Pronunciation/fəˈmɒtɪdiːn/
Trade namesPepcid, Zantac 360, others
AHFS/Drugs.comMonograph
MedlinePlusa687011
License data
Pregnancy
category
Routes of
administration		By mouth, intravenous
Drug classHistamine H2 receptor antagonist
ATC code
Legal status
Legal status
  • AU: S3 (Pharmacist only) / S4
  • UK: POM (Prescription only)
  • US: OTC / Rx-only[2][3]
Pharmacokinetic data
Bioavailability40–45% (by mouth)[2]
Protein binding15–20%[2]
Onset of action90 minutes
Elimination half-life2.5–3.5 hours[2]
Duration of action9 hours
ExcretionKidney (25–30% unchanged [Oral])[2]
Identifiers
IUPAC name
  • 3-[({2-[(diaminomethylidene)amino]-1,3-thiazol-4-yl}methyl)sulfanyl]-N-sulfamoylpropanimidamide
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
PDB ligand
CompTox Dashboard (EPA)
ECHA InfoCard100.116.793
Chemical and physical data
FormulaC8H15N7O2S3
Molar mass337.44 g·mol−1
3D model (JSmol)
SMILES
  • NS(=O)(=O)/N=C(\N)CCSCc1csc(n1)N=C(N)N
InChI
  • InChI=1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14) Y
  • Key:XUFQPHANEAPEMJ-UHFFFAOYSA-N Y
  (verify)

Famotidine, sold under the brand name Pepcid among others, is a histamine H2 receptor antagonist medication that decreases stomach acid production.[4] It is used to treat peptic ulcer disease, gastroesophageal reflux disease, and Zollinger–Ellison syndrome.[4] It is taken by mouth or by injection into a vein.[4] It begins working within an hour.[4]

Common side effects include headache, abdominal pain, diarrhea or constipation, and dizziness.[4] Serious side effects may include pneumonia and seizures.[4][5] Use in pregnancy appears safe but has not been well studied, while use during breastfeeding is not recommended.[1]

Famotidine was patented in 1979 and came into medical use in 1985.[6] It is available as a generic medication.[5] In 2022, it was the 49th most commonly prescribed medication in the United States, with more than 13 million prescriptions.[7][8]

  1. ^ a b "Famotidine Pregnancy and Breastfeeding Warnings". Drugs.com. Archived from the original on 16 December 2023. Retrieved 3 March 2019.
  2. ^ a b c d e "Famotidine tablet". DailyMed. Archived from the original on 31 March 2024. Retrieved 6 March 2021.
  3. ^ "Zantac 360- famotidine tablet, film coated". DailyMed. 17 May 2022. Archived from the original on 6 July 2022. Retrieved 6 July 2022.
  4. ^ a b c d e f "Famotidine Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 17 June 2019. Retrieved 3 March 2019.
  5. ^ a b British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 74–75. ISBN 9780857113382.
  6. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 444. ISBN 9783527607495. Archived from the original on 29 July 2020. Retrieved 7 May 2020.
  7. ^ "The Top 300 of 2022". ClinCalc. Archived from the original on 30 August 2024. Retrieved 30 August 2024.
  8. ^ "Famotidine Drug Usage Statistics, United States, 2013 - 2022". ClinCalc. Archived from the original on 17 April 2020. Retrieved 30 August 2024.
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