Fluticasone propionate

For other uses, see Fluticasone.

Fluticasone propionate
Clinical data
Trade namesFlovent, Flixotide, Flonase, others
AHFS/Drugs.comMonograph
MedlinePlusa695002
License data
Pregnancy
category
Routes of
administration		Intranasal,[2] inhalation,[3] topical[4]
Drug classGlucocorticoid
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability0.51% (Intranasal)
Protein binding91%
MetabolismIntranasal
Liver (CYP3A4-mediated)
Elimination half-life10 hours
ExcretionKidney
Identifiers
IUPAC name
  • S-(fluoromethyl)-6α,9-difluoro-11β, 17-dihydroxy-16α-methyl-3-oxoandrosta-1, 4-diene-17β-carbothioate, 17-propanoate
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.129.097
Chemical and physical data
FormulaC25H31F3O5S
Molar mass500.57 g·mol−1
3D model (JSmol)
SMILES
  • CCC(=O)OC1(C(CC2C1(CC(C3(C2CC(C4=CC(=O)C=CC43C)F)F)O)C)C)C(=O)SCF
InChI
  • InChI=1S/C25H31F3O5S/c1-5-20(31)33-25(21(32)34-12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15+,16+,18+,19+,22+,23+,24+,25+/m1/s1 Y
  • Key:WMWTYOKRWGGJOA-CENSZEJFSA-N Y
  (verify)

Fluticasone propionate, sold under the brand names Flovent and Flonase among others, is a glucocorticoid steroid medication.[8] When inhaled it is used for the long term management of asthma and chronic obstructive pulmonary disease (COPD).[8] In the nose it is used for hay fever and nasal polyps.[9][10] It can also be used for mouth ulcers.[11] It works by decreasing inflammation.

Common side effects when inhaled include upper respiratory tract infections, sinusitis, thrush, and cough.[8] Common side effects when used in the nose include nosebleeding and sore throat.[9] Unlike fluticasone furoate, which is approved in children as young as two years of age when used for allergies, fluticasone propionate is only approved for children four years and older.[12][13]

Fluticasone propionate was patented in 1980, and approved for medical use in 1990.[14] It is available as a generic medication.[10] In 2022, fluticasone was the 25th most commonly prescribed medication in the United States, with more than 22 million prescriptions.[15][16]

  1. ^ "Fluticasone Use During Pregnancy". Drugs.com. 9 January 2019. Archived from the original on 26 March 2019. Retrieved 31 January 2020.
  2. ^ Cite error: The named reference Flonase Allergy Relief FDA label was invoked but never defined (see the help page).
  3. ^ Cite error: The named reference Flovent Diskus FDA label was invoked but never defined (see the help page).
  4. ^ a b "Cutivate- fluticasone propionate lotion". DailyMed. 8 August 2018. Archived from the original on 20 February 2022. Retrieved 19 February 2022.
  5. ^ "Prescription medicines: registration of new generic medicines and biosimilar medicines, 2017". Therapeutic Goods Administration (TGA). 21 June 2022. Retrieved 30 March 2024.
  6. ^ "Respiratory health". Health Canada. 9 May 2018. Retrieved 13 April 2024.
  7. ^ "Flixonase Aqueous Nasal Spray - Summary of Product Characteristics (SmPC)". (emc). 25 October 2019. Archived from the original on 31 January 2020. Retrieved 31 January 2020.
  8. ^ a b c "Fluticasone Propionate Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 28 February 2019. Retrieved 27 February 2019.
  9. ^ a b "Fluticasone Propionate eent Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 28 February 2019. Retrieved 27 February 2019.
  10. ^ a b British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 262, 1172. ISBN 9780857113382.
  11. ^ "Flixonase aqueous spray" (PDF). Sheffield Teaching Hospitals. June 2018. Archived from the original (PDF) on 25 September 2019. Retrieved 31 January 2020.
  12. ^ "Flonase Sensimist Allergy Relief- fluticasone furoate spray, metered". DailyMed. 30 May 2019. Archived from the original on 2 December 2020. Retrieved 4 February 2020.
  13. ^ "Veramyst- fluticasone furoate spray, metered". DailyMed. 1 March 2010. Archived from the original on 5 February 2020. Retrieved 4 February 2020.
  14. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 487. ISBN 9783527607495. Archived from the original on 28 November 2023. Retrieved 19 September 2020.
  15. ^ "The Top 300 of 2022". clincalc.com. Retrieved 19 August 2024.
  16. ^ "Fluticasone - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
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