Follicular dendritic cells

Follicular dendritic cells (FDC) are cells of the immune system found in primary and secondary lymph follicles (lymph nodes) of the B cell areas of the lymphoid tissue.[1][2][3] Unlike dendritic cells (DC), FDCs are not derived from the bone-marrow hematopoietic stem cell, but are of mesenchymal origin.[4] Possible functions of FDC include: organizing lymphoid tissue's cells and microarchitecture, capturing antigen to support B cell, promoting debris removal from germinal centers, and protecting against autoimmunity. Disease processes that FDC may contribute include primary FDC-tumor, chronic inflammatory conditions, HIV-1 infection development, and neuroinvasive scrapie.

  1. ^ Liu Y, Grouard G, de Bouteiller O, Banchereau J (1996). Follicular Dendritic Cells and Germinal Centers. International Review of Cytology. Vol. 166. pp. 139–79. doi:10.1016/S0074-7696(08)62508-5. ISBN 978-0-12-364570-8. PMID 8881775. {{cite book}}: |journal= ignored (help)
  2. ^ Heesters, Balthasar A.; Myers, Riley C.; Carroll, Michael C. (2014-06-20). "Follicular dendritic cells: dynamic antigen libraries". Nature Reviews Immunology. 14 (7): 495–504. doi:10.1038/nri3689. ISSN 1474-1733. PMID 24948364. S2CID 7082877.
  3. ^ Aguzzi, Adriano; Kranich, Jan; Krautler, Nike Julia (March 2014). "Follicular dendritic cells: origin, phenotype, and function in health and disease". Trends in Immunology. 35 (3): 105–113. doi:10.1016/j.it.2013.11.001. ISSN 1471-4906. PMID 24315719.
  4. ^ Banchereau J, Steinman RM (1998). "Dendritic cells and the control of immunity". Nature. 392 (6673): 245–52. Bibcode:1998Natur.392..245B. doi:10.1038/32588. PMID 9521319. S2CID 4388748.van Nierop K, de Groot C (2002). "Human follicular dendritic cells: function, origin and development". Semin Immunol. 14 (4): 251–7. doi:10.1016/S1044-5323(02)00057-X. PMID 12163300.
This article is issued from Wikipedia. The text is available under Creative Commons Attribution-Share Alike 4.0 unless otherwise noted. Additional terms may apply for the media files.