Fomepizole

Fomepizole
	Chemical structure of fomepizole
Clinical data
Pronunciation	/ˌfoʊˈmɛpɪzoʊl/
Trade names	Antizol, others
Other names	4-Methylpyrazole
AHFS/Drugs.com	Monograph
License data	US DailyMed: Fomepizole;
Routes of; administration	Intravenous
Drug class	Alcohol dehydrogenase inhibitor
ATC code	V03AB34 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); US: ℞-only;
Identifiers
	IUPAC name 4-Methyl-1H-pyrazole;
CAS Number	7554-65-6 ;
PubChem CID	3406;
DrugBank	DB01213;
ChemSpider	3289;
UNII	83LCM6L2BY;
KEGG	D00707;
ChEBI	CHEBI:5141;
ChEMBL	ChEMBL1308;
CompTox Dashboard (EPA)	DTXSID3040649 ;
ECHA InfoCard	100.028.587
Chemical and physical data
Formula	C4H6N2
Molar mass	82.106 g·mol−1
3D model (JSmol)	Interactive image;
Density	0.99 g/cm3
Boiling point	204 to 207 °C (399 to 405 °F) (at 97,3 kPa)
	SMILES CC1=CNN=C1;
	InChI InChI=1S/C4H6N2/c1-4-2-5-6-3-4/h2-3H,1H3,(H,5,6) ; Key:RIKMMFOAQPJVMX-UHFFFAOYSA-N;

Fomepizole, also known as 4-methylpyrazole, is a medication used to treat methanol and ethylene glycol poisoning.^[3] It may be used alone or together with hemodialysis.^[3] It is given by injection into a vein.^[3]

Common side effects include headache, nausea, sleepiness, and unsteadiness.^[3] It is unclear if use during pregnancy causes risk to a fetus.^[3] Fomepizole works by blocking the enzyme that converts methanol and ethylene glycol to their toxic breakdown products.^[3]

Fomepizole was approved for medical use in the United States in 1997.^[3] It is on the World Health Organization's List of Essential Medicines.^[4]

^ "Prescription medicines: registration of new chemical entities in Australia, 2016". Therapeutic Goods Administration (TGA). 21 June 2022. Retrieved 10 April 2023.
^ "Antizol- fomepizole injection". DailyMed. U.S. National Library of Medicine. Retrieved 24 December 2020.
^ ^a ^b ^c ^d ^e ^f ^g "Fomepizole". The American Society of Health-System Pharmacists. Archived from the original on 21 December 2016. Retrieved 8 December 2016.
^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.

[1] "Prescription medicines: registration of new chemical entities in Australia, 2016". Therapeutic Goods Administration (TGA). 21 June 2022. Retrieved 10 April 2023.

[2] "Antizol- fomepizole injection". DailyMed. U.S. National Library of Medicine. Retrieved 24 December 2020.

[AHFS2016-3] ^ ^a ^b ^c ^d ^e ^f ^g "Fomepizole". The American Society of Health-System Pharmacists. Archived from the original on 21 December 2016. Retrieved 8 December 2016.

[World_Health_Organization_2019-4] World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.

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