Fremanezumab

Fremanezumab
A Norwegian syringe of fremanezumab
Monoclonal antibody
TypeWhole antibody
SourceHumanized
TargetCalcitonin gene-related peptide (CGRP) α, β
Clinical data
Trade namesAjovy
Other namesTEV-48125, fremanezumab-vfrm
AHFS/Drugs.comMonograph
MedlinePlusa618053
License data
Pregnancy
category
Routes of
administration		Subcutaneous
Drug classCalcitonin gene-related peptide antagonist
ATC code
Legal status
Legal status
Identifiers
CAS Number
DrugBank
ChemSpider
  • none
UNII
KEGG
Chemical and physical data
FormulaC6470H9952N1716O2016S46
Molar mass145507.54 g·mol−1

Fremanezumab, sold under the brand name Ajovy, is a medication used to prevent migraines.[6][8] It is given by subcutaneous injection (injection under the skin).[6][8]

The most common side effect is pain and redness at the site of injection.[8] Other side effects include allergic reactions.[8] It is a calcitonin gene-related peptide antagonist.[6][8]

It was approved for medical use in the United States in 2018,[8] the European Union in 2019,[7] the United Kingdom in 2020,[4] and Argentina by September 2021.[9]

  1. ^ "Fremanezumab Pregnancy and Breastfeeding Warnings". Drugs.com. 3 October 2018. Retrieved 2 April 2020.
  2. ^ "Summary Basis of Decision (SBD) for Ajovy". Health Canada. Retrieved 29 May 2022.
  3. ^ "Ajovy Product information". Health Canada. Retrieved 31 May 2022.
  4. ^ a b "Fremanezumab". NICE - National Institute for Health and Care Excellence. Retrieved 25 June 2021.
  5. ^ "Ajovy (fremanezumab) 225 mg Pre-filled Syringe for Injection - Summary of Product Characteristics (SmPC)". (emc). Retrieved 27 September 2021.
  6. ^ a b c d "Ajovy- fremanezumab-vfrm injection". DailyMed. U.S. National Library of Medicine. 5 February 2020. Retrieved 2 April 2020.
  7. ^ a b "Ajovy EPAR". European Medicines Agency (EMA). 29 January 2019. Retrieved 2 April 2020.
  8. ^ a b c d e f "Fremanezumab-vfrm Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 15 July 2019.
  9. ^ "Migraña: en qué consiste el nuevo tratamiento para esta enfermedad frecuente e incapacitante". 12 September 2021.
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