Fusidic acid

Fusidic acid
Clinical data
Trade names	Fucidin, Foban, others
Other names	Sodium fusidate
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Routes of; administration	Topical
ATC code	D06AX01 (WHO) D09AA02 (WHO) (dressing) J01XC01 (WHO) S01AA13 (WHO);
Legal status
Legal status	NZ: Prescription only; UK: POM (Prescription only); US: OTC / Not approved; In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	91% oral bioavailability
Protein binding	97 to 99%
Elimination half-life	Approximately 5 to 6 hours in adults
Identifiers
	IUPAC name 2-[(1S,2S,5R,6S,7S,10S,11S,13S,14Z,15R,17R)-13-(acetyloxy)-5,17-dihydroxy-2,6,10,11-tetramethyltetracyclo[8.7.0.02,7.011,15]heptadecan-14-ylidene]-6-methylhept-5-enoic acid;
CAS Number	6990-06-3 ;
PubChem CID	3000226;
DrugBank	DB02703 ;
ChemSpider	2271900 ;
UNII	59XE10C19C; J7P3696BCQ;
KEGG	D04281 ; D00213;
ChEBI	CHEBI:29013 ;
ChEMBL	ChEMBL374975 ;
PDB ligand	FUA (PDBe, RCSB PDB);
CompTox Dashboard (EPA)	DTXSID0023086 ;
ECHA InfoCard	100.027.506
Chemical and physical data
Formula	C31H48O6
Molar mass	516.719 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(O)/C(=C3/[C@@H]2C[C@@H](O)[C@H]1[C@@]4(C)CC[C@@H](O)[C@@H](C)[C@@H]4CC[C@@]1([C@]2(C[C@@H]3OC(=O)C)C)C)CC\C=C(/C)C;
	InChI InChI=1S/C31H48O6/c1-17(2)9-8-10-20(28(35)36)26-22-15-24(34)27-29(5)13-12-23(33)18(3)21(29)11-14-30(27,6)31(22,7)16-25(26)37-19(4)32/h9,18,21-25,27,33-34H,8,10-16H2,1-7H3,(H,35,36)/b26-20-/t18-,21-,22-,23+,24+,25-,27-,29-,30-,31-/m0/s1 ; Key:IECPWNUMDGFDKC-MZJAQBGESA-N ;
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Fusidic acid, sold under the brand name Fucidin among others, is a steroid antibiotic that is often used topically in creams or ointments and eyedrops but may also be given systemically as tablets or injections. As of October 2008, the global problem of advancing antimicrobial resistance has led to a renewed interest in its use.^[3]

^ "About fusidic acid". NHS. London. 30 November 2021. Retrieved 7 May 2024.
^ "Fucidin- sodium fusidate ointment". DailyMed. 6 November 2019. Retrieved 5 May 2024.
^ Falagas ME, Grammatikos AP, Michalopoulos A (October 2008). "Potential of old-generation antibiotics to address current need for new antibiotics". Expert Review of Anti-Infective Therapy. 6 (5): 593–600. doi:10.1586/14787210.6.5.593. PMID 18847400. S2CID 13158593.

[NHS-1] "About fusidic acid". NHS. London. 30 November 2021. Retrieved 7 May 2024.

[2] "Fucidin- sodium fusidate ointment". DailyMed. 6 November 2019. Retrieved 5 May 2024.

[Falagas-2008""-3] Falagas ME, Grammatikos AP, Michalopoulos A (October 2008). "Potential of old-generation antibiotics to address current need for new antibiotics". Expert Review of Anti-Infective Therapy. 6 (5): 593–600. doi:10.1586/14787210.6.5.593. PMID 18847400. S2CID 13158593.

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