GS-441524

GS-441524
Legal status
Legal status
  • AU: Yes
  • UK: Yes
  • US: Investigational drug
  • EU: No, legal treatment available in the Netherlands
Identifiers
IUPAC name
  • (2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-carbonitrile
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
Chemical and physical data
FormulaC12H13N5O4
Molar mass291.267 g·mol−1
3D model (JSmol)
SMILES
  • C1=C2C(=NC=NN2C(=C1)[C@]3([C@@H]([C@@H]([C@H](O3)CO)O)O)C#N)N
InChI
  • InChI=1S/C12H13N5O4/c13-4-12(10(20)9(19)7(3-18)21-12)8-2-1-6-11(14)15-5-16-17(6)8/h1-2,5,7,9-10,18-20H,3H2,(H2,14,15,16)/t7-,9-,10-,12+/m1/s1
  • Key:BRDWIEOJOWJCLU-LTGWCKQJSA-N

GS-441524 is a nucleoside analogue antiviral drug which was developed by Gilead Sciences. It is the main plasma metabolite of the antiviral prodrug remdesivir, and has a half-life of around 24 hours in human patients. Remdesivir and GS-441524 were both found to be effective in vitro against feline coronavirus strains responsible for feline infectious peritonitis (FIP), a lethal systemic disease affecting domestic cats. Remdesivir was never tested in cats (though some vets now offer it[1]), but GS-441524 has been found to be effective treatment for FIP.

It is widely used despite no official FDA approval due to Gilead's refusal to license this drug for veterinary use.[2][3][4][5] In several countries oral GS-441524 tablets (and injectable remdesivir) became legally available to vets for the treatment of FIP in cats, for example Australia,[6] the Netherlands,[7][a] and the United Kingdom.[6]

Besides remdesivir, other prodrugs include obeldesivir (Gilead Sciences, Phase III) and deuremidevir (Vigonvita/Junshi, conditional approval in China).

  1. ^ "Veterinary advancements in managing Feline Infectious Peritonitis (FIP) in cats". Australian Veterinary Association Ltd. 19 February 2021.
  2. ^ Westgate J (7 May 2020). "Vet science 'being ignored' in quest for COVID-19 drug". vet times. Retrieved 6 July 2020.
  3. ^ Zhang S (8 May 2020). "A Much-Hyped COVID-19 Drug Is Almost Identical to a Black-Market Cat Cure". The Atlantic. Retrieved 6 July 2020.
  4. ^ Murphy BG, Perron M, Murakami E, Bauer K, Park Y, Eckstrand C, et al. (June 2018). "The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies". Veterinary Microbiology. 219: 226–233. doi:10.1016/j.vetmic.2018.04.026. PMC 7117434. PMID 29778200.
  5. ^ Pedersen NC, Perron M, Bannasch M, Montgomery E, Murakami E, Liepnieks M, Liu H (April 2019). "Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis". Journal of Feline Medicine and Surgery. 21 (4): 271–281. doi:10.1177/1098612X19825701. PMC 6435921. PMID 30755068.
  6. ^ a b "Feline Infectious Peritonitis (FIP)". icatcare.org. International Cat Care. Retrieved 2023-10-15.
  7. ^ "Nu ook in Nederland behandeling voor katten met FIP". www.licg.nl (in Dutch). Landelijk InformatieCentrum Gezelschapsdieren (LICG). Retrieved 2023-10-15.
  8. ^ "Cascade". cbg-meb.nl. Medicines Evaluation Board. 6 October 2018. Retrieved 2023-10-15.


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