GeneCards

GeneCards
Content
Data types
captured		Human genes and model orthologues
OrganismsHomo sapiens
Contact
Research centerCrown Human Genome Center, WIS
Primary citationPMID 9097728
Access
Data formatHTML
Websitewww.genecards.org

GeneCards is a database of human genes that provides genomic, proteomic, transcriptomic, genetic and functional information on all known and predicted human genes.[1][2][3][4] It is being developed and maintained by the Crown Human Genome Center at the Weizmann Institute of Science, in collaboration with LifeMap Sciences.

The database aims at providing a comprehensive view of the current available biomedical information about the searched gene, including its aliases and identifiers, the encoded proteins, associated diseases and variations, its function, relevant publications and more.[1][5][6] The GeneCards database provides access to free Web resources about more than 350,000 known and predicted human genes, integrated from >150 data resources, such as HGNC, Ensembl, and NCBI. The core gene list is based on NCBI, Ensembl and approved gene symbols published by the HUGO Gene Nomenclature Committee (HGNC).[7][8] The information is carefully gathered and selected from these databases by its integration engine.

Over time, the GeneCards database has developed a suite of tools (VarElect, GeneALaCart, etc.) that have more specialised capabilities leveraging the database. Since 1998, the GeneCards database has been widely used by bioinformatics, genomics and medical communities for more than 24 years.[7][8]

  1. ^ a b Rebhan M, Chalifa-Caspi V, Prilusky J, Lancet D (April 1997). "GeneCards: integrating information about genes, proteins and diseases". Trends in Genetics. 13 (4): 163. doi:10.1016/S0168-9525(97)01103-7. PMID 9097728.
  2. ^ Rebhan M, Chalifa-Caspi V, Prilusky J, Lancet D (1998). "GeneCards: a novel functional genomics compendium with automated data mining and query reformulation support". Bioinformatics. 14 (8): 656–64. doi:10.1093/bioinformatics/14.8.656. PMID 9789091.
  3. ^ Safran M, Solomon I, Shmueli O, Lapidot M, Shen-Orr S, Adato A, et al. (November 2002). "GeneCards 2002: towards a complete, object-oriented, human gene compendium". Bioinformatics. 18 (11): 1542–3. doi:10.1093/bioinformatics/18.11.1542. PMID 12424129.
  4. ^ Harel A, Inger A, Stelzer G, Strichman-Almashanu L, Dalah I, Safran M, Lancet D (October 2009). "GIFtS: annotation landscape analysis with GeneCards". BMC Bioinformatics. 10 (1) 348. doi:10.1186/1471-2105-10-348. PMC 2774327. PMID 19852797.
  5. ^ "GeneCards". GeneCards. Archived from the original on 2013-10-14. Retrieved 18 Oct 2013.
  6. ^ "GeneCards". Retrieved 19 Oct 2013.
  7. ^ a b Cite error: The named reference pmid22155609 was invoked but never defined (see the help page).
  8. ^ a b Cite error: The named reference pmid20689021 was invoked but never defined (see the help page).
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