Germ cell tumor

Germ-cell tumor
Micrograph of a seminoma, a common germ cell tumor.
SpecialtyOncology

A germ cell tumor (GCT) is a neoplasm derived from primordial germ cells.[1] Germ-cell tumors can be cancerous or benign. Germ cell tumors typically originate from the gonads (ovary[2] and testis), but can arise in other areas of the body. Extragonadal GCTs are thought to result from abnormal migration of germ cell precursors during development of the embryo.[3]

  1. ^ Harrison's principles of internal medicine (21st ed.). New York: McGraw Hill. 2022. p. 690. ISBN 978-1-264-26850-4.
  2. ^ Maoz A, Matsuo K, Ciccone MA, Matsuzaki S, Klar M, Roman LD, et al. (May 2020). "Molecular Pathways and Targeted Therapies for Malignant Ovarian Germ Cell Tumors and Sex Cord-Stromal Tumors: A Contemporary Review". Cancers. 12 (6): 1398. doi:10.3390/cancers12061398. PMC 7353025. PMID 32485873.
  3. ^ Glenn, OA and Barkovich AJ (1996). "Intracranial germ cell tumors: a comprehensive review of proposed embryologic derivation". Pediatric Neurosurgery. 24 (5): 242–251. doi:10.1159/000121046. PMID 8933567.
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