Glandular odontogenic cyst

Glandular odontogenic cyst
Other namesSialo-Odontogenic cyst
Relative incidence of odontogenic cysts.[1] Glandular odontogenic cyst is labeled at bottom.
SymptomsJaw expansion, swelling, impairment to the tooth, root and cortical plate [2][3]
CausesCellular mutation, cyst maturation at glandular, BCL-2 protein [2][4]
Diagnostic methodBiopsy, CT scans, Panoramic x-rays [5][6]
Differential diagnosisCentral mucoepidermoid carcinoma, odontogenic keratocyst [7][6]
PreventionPost-surgery follow-ups are commonly proposed to prevent the chances of recurrence [6]
TreatmentEnucleation, curettage, marginal or partial resection, marsupialization[6]
Frequency0.12 to 0.13% of people [2]

A glandular odontogenic cyst (GOC) is a rare and usually benign odontogenic cyst developed at the odontogenic epithelium of the mandible or maxilla.[2][8][9][10] Originally, the cyst was labeled as "sialo-odontogenic cyst" in 1987.[7] However, the World Health Organization (WHO) decided to adopt the medical expression "glandular odontogenic cyst".[9] Following the initial classification, only 60 medically documented cases were present in the population by 2003.[6] GOC was established as its own biological growth after differentiation from other jaw cysts such as the "central mucoepidermoid carcinoma (MEC)", a popular type of neoplasm at the salivary glands.[7][11] GOC is usually misdiagnosed with other lesions developed at the glandular and salivary gland due to the shared clinical signs.[12] The presence of osteodentin supports the concept of an odontogenic pathway.[10] This odontogenic cyst is commonly described to be a slow and aggressive development.[13] The inclination of GOC to be large and multilocular is associated with a greater chance of remission.[10][3] GOC is an infrequent manifestation with a 0.2% diagnosis in jaw lesion cases.[14] Reported cases show that GOC mainly impacts the mandible and male individuals.[3] The presentation of GOC at the maxilla has a very low rate of incidence.[8] The GOC development is more common in adults in their fifth and sixth decades.[1]

GOC has signs and symptoms of varying sensitivities, and dysfunction.[13][14] In some cases, the GOC will present no classic abnormalities and remains undiagnosed until secondary complications arise.[13] The proliferation of GOC requires insight into the foundations of its unique histochemistry and biology.[7] The comparable characteristics of GOC with other jaw lesions require the close examination of its histology, morphology, and immunocytochemistry for a differential diagnosis.[10] Treatment modes of the GOC follow a case-by-case approach due to the variable nature of the cyst.[5] The selected treatment must be accompanied with an appropriate pre and post-operative plan.[5]

  1. ^ a b Borges, Leandro Bezerra; Fechine, Francisco Vagnaldo; Mota, Mário Rogério Lima; Sousa, Fabrício Bitu; Alves, Ana Paula Negreiros Nunes (March 2012). "Odontogenic lesions of the jaw: a clinical-pathological study of 461 cases". Revista Gaúcha de Odontologia. 60 (1): 71–78. S2CID 46982083.
  2. ^ a b c d Faisal, Mohammad; Ahmad, Syed Ansar; Ansari, Uzma (September 2015). "Glandular odontogenic cyst – Literature review and report of a paediatric case". Journal of Oral Biology and Craniofacial Research. 5 (3): 219–225. doi:10.1016/j.jobcr.2015.06.011. PMC 4623883. PMID 26587384.
  3. ^ a b c Momeni Roochi, Mehrnoush; Tavakoli, Iman; Ghazi, Fatemeh Mojgan; Tavakoli, Ali (1 July 2015). "Case series and review of glandular odontogenic cyst with emphasis on treatment modalities". Journal of Cranio-Maxillofacial Surgery. 43 (6): 746–750. doi:10.1016/j.jcms.2015.03.030. PMID 25971944.
  4. ^ Cite error: The named reference pmid24959044 was invoked but never defined (see the help page).
  5. ^ a b c Cano, Jorge; Benito, Dulce María; Montáns, José; Rodríguez-Vázquez, José Francisco; Campo, Julián; Colmenero, César (1 July 2012). "Glandular odontogenic cyst: Two high-risk cases treated with conservative approaches". Journal of Cranio-Maxillofacial Surgery. 40 (5): e131 – e136. doi:10.1016/j.jcms.2011.07.005. PMID 21865053.
  6. ^ a b c d e Kaplan, Ilana; Gal, Gavriel; Anavi, Yakir; Manor, Ronen; Calderon, Shlomo (April 2005). "Glandular odontogenic cyst: Treatment and recurrence". Journal of Oral and Maxillofacial Surgery. 63 (4): 435–441. doi:10.1016/j.joms.2004.08.007. PMID 15789313.
  7. ^ a b c d Shear, Mervyn; Speight, Paul, eds. (2007). "Glandular Odontogenic Cyst (Sialo-Odontogenic Cyst)". Cysts of the Oral and Maxillofacial Regions. pp. 94–99. doi:10.1002/9780470759769.ch7. ISBN 978-0-470-75976-9.
  8. ^ a b Prabhu, Sudeendra; Rekha, K; Kumar, GS (2010). "Glandular odontogenic cyst mimicking central mucoepidermoid carcinoma". Journal of Oral and Maxillofacial Pathology. 14 (1): 12–5. doi:10.4103/0973-029X.64303. PMC 2996005. PMID 21180452.
  9. ^ a b Motooka, Naomi; Ohba, Seigo; Uehara, Masataka; Fujita, Syuichi; Asahina, Izumi (1 January 2015). "A case of glandular odontogenic cyst in the mandible treated with the dredging method". Odontology. 103 (1): 112–115. doi:10.1007/s10266-013-0143-0. PMID 24374982. S2CID 21059170.
  10. ^ a b c d Shah, AmishaA; Sangle, Amit; Bussari, Smita; Koshy, AjitV (2016). "Glandular odontogenic cyst: A diagnostic dilemma". Indian Journal of Dentistry. 7 (1): 38–43. doi:10.4103/0975-962X.179371. PMC 4836096. PMID 27134453.
  11. ^ Nagasaki, Atsuhiro; Ogawa, Ikuko; Sato, Yukiko; Takeuchi, Kengo; Kitagawa, Masae; Ando, Toshinori; Sakamoto, Shinnichi; Shrestha, Madhu; Uchisako, Kaori; Koizumi, Koichi; Toratani, Shigeaki; Konishi, Masaru; Takata, Takashi (January 2018). "Central mucoepidermoid carcinoma arising from glandular odontogenic cyst confirmed by analysis of MAML2 rearrangement: A case report: Central MEC arising from GOC". Pathology International. 68 (1): 31–35. doi:10.1111/pin.12609. PMID 29131467. S2CID 8932602.
  12. ^ AbdullGaffar, Badr; Koilelat, Mohamed (May 2017). "Glandular Odontogenic Cyst: The Value of Intraepithelial Hemosiderin". International Journal of Surgical Pathology. 25 (3): 250–252. doi:10.1177/1066896916672333. PMID 27829208. S2CID 46588216.
  13. ^ a b c Akkaş, İsmail; Toptaş, Orçun; Özan, Fatih; Yılmaz, Fahri (1 March 2015). "Bilateral Glandular Odontogenic Cyst of Mandible: A Rare Occurrence". Journal of Maxillofacial and Oral Surgery. 14 (1): 443–447. doi:10.1007/s12663-014-0668-y. PMC 4379287. PMID 25848155.
  14. ^ a b Neville, Brad W. (2016). "Cyst, Glandular Odontogenic". In Slootweg, Pieter (ed.). Dental and Oral Pathology. Encyclopedia of Pathology. Springer International Publishing. pp. 89–93. doi:10.1007/978-3-319-28085-1_677. ISBN 978-3-319-28084-4.
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