Glomerular hyperfiltration

Glomerular hyperfiltration
Diagram showing a schematic nephron and its blood supply.

Glomerular hyperfiltration is a situation where the filtration elements in the kidneys called glomeruli produce excessive amounts of pro-urine. It can be part of a number of medical conditions particularly diabetic nephropathy (kidney damage associated with diabetes).[1]

There is no universally accepted definition of glomerular hyperfiltration, and little research has been done on the pathophysiological mechanisms, which are likely to change depending on the underlying ailment.[2]

Glomerular hyperfiltration can result from efferent arteriolar vasoconstriction due to activation of the renin–angiotensin–aldosterone system, which causes glomerular hypertension, or afferent arteriolar vasodilation, as observed in diabetic patients or following a high-protein meal.[2]

  1. ^ Cachat, F; Combescure, C; Cauderay, M; Girardin, E; Chehade, H (7 January 2015). "A Systematic Review of Glomerular Hyperfiltration Assessment and Definition in the Medical Literature". Clinical Journal of the American Society of Nephrology. 10 (3): 382–9. doi:10.2215/CJN.03080314. PMC 4348676. PMID 25568216.
  2. ^ a b Cite error: The named reference Helal Fick-Brosnahan Reed-Gitomer Schrier 2012 pp. 293–300 was invoked but never defined (see the help page).
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