Hürthle cell

Hürthle cell
Other namesAskanazy cell
Micrograph showing Hürthle cells in a Hürthle cell neoplasm. Pap stain.
Pronunciation
  • /ˈhɪərtlə/
SpecialtyPathology

A Hürthle cell is a transformed (metaplasia) thyroid follicular cell with "enlarged mitochondria and enlarged round nuclei with prominent nucleoli", resulting in eosinophilia in the cytoplasm.[1]

Oncocytes in the thyroid are often called Hürthle cells. Although the terms oncocyte, oxyphil cell, and Hürthle cell are used interchangeably, "Hürthle cell" is used only to indicate cells of thyroid follicular origin.[2]

  1. ^ Robertson, R. Paul (2022). DeGroot's Endocrinology, E-Book: Basic Science and Clinical Practice (8th ed.). Philadelphia: Elsevier. p. 1166. ISBN 978-0-323-69412-4.
  2. ^ Cannon, J. (2011). The Significance of Hurthle Cells in Thyroid Disease. The Oncologist. doi:10.1634/theoncologist.2010-0253
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