HER2

ERBB2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1MFG, 1MFL, 1MW4, 1N8Z, 1QR1, 1S78, 2A91, 2JWA, 2KS1, 2L4K, 3BE1, 3H3B, 3N85, 3PP0, 3RCD, 3MZW, 3WLW, 3WSQ, 4GFU, 4HRL, 4HRM, 4HRN, 2N2A
Identifiers
Aliases	ERBB2, CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1, erb-b2 receptor tyrosine kinase 2
External IDs	OMIM: 164870; MGI: 95410; HomoloGene: 3273; GeneCards: ERBB2; OMA:ERBB2 - orthologs
EC number	2.7.10.1
Gene location (Human)
Chr.	Chromosome 17 (human)
End	39,730,426 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	98,328,542 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; sural nerve; ; skin of leg; ; skin of abdomen; ; renal medulla; ; minor salivary glands; ; right lobe of thyroid gland; ; olfactory zone of nasal mucosa; ; mucosa of transverse colon; ; left lobe of thyroid gland;
	Top expressed in
	lip; ; intestinal villus; ; middle ear; ; Eustachian tube; ; oral mucosa; ; esophagus; ; colon; ; crypt of lieberkuhn of small intestine; ; right kidney; ; left colon;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	ErbB-3 class receptor binding; transferase activity; nucleotide binding; protein kinase activity; protein dimerization activity; growth factor binding; RNA polymerase I core binding; kinase activity; protein C-terminus binding; protein binding; identical protein binding; protein heterodimerization activity; transmembrane receptor protein tyrosine kinase activity; protein tyrosine kinase activity; protein phosphatase binding; ATP binding; transmembrane signaling receptor activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; receptor tyrosine kinase;
Cellular component	integral component of membrane; membrane; myelin sheath; receptor complex; plasma membrane; basolateral plasma membrane; apical plasma membrane; perinuclear region of cytoplasm; endosome membrane; cytoplasmic vesicle; nucleus; cytoplasm; cytosol; integral component of plasma membrane; basal plasma membrane;
Biological process	positive regulation of protein phosphorylation; peripheral nervous system development; regulation of transcription, DNA-templated; negative regulation of immature T cell proliferation in thymus; positive regulation of MAP kinase activity; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of epithelial cell proliferation; cellular response to growth factor stimulus; wound healing; oligodendrocyte differentiation; regulation of angiogenesis; positive regulation of translation; transcription, DNA-templated; nervous system development; MAPK cascade; protein phosphorylation; heart development; cell surface receptor signaling pathway; positive regulation of GTPase activity; positive regulation of cell growth; regulation of microtubule-based process; neuromuscular junction development; regulation of ERK1 and ERK2 cascade; myelination; protein autophosphorylation; phosphatidylinositol 3-kinase signaling; positive regulation of transcription by RNA polymerase I; cell population proliferation; positive regulation of transcription by RNA polymerase III; motor neuron axon guidance; enzyme linked receptor protein signaling pathway; signal transduction; positive regulation of cell adhesion; positive regulation of protein targeting to membrane; ERBB2 signaling pathway; phosphatidylinositol phosphate biosynthetic process; positive regulation of gene expression; peptidyl-tyrosine phosphorylation; regulation of cell motility; cellular response to epidermal growth factor stimulus; regulation of transcription by RNA polymerase II; negative regulation of ERBB signaling pathway; positive regulation of protein kinase B signaling; negative regulation of signal transduction; cell differentiation; negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade; intracellular signal transduction; positive regulation of cell population proliferation; neuron differentiation; positive regulation of MAPK cascade;
	Sources:Amigo / QuickGO
Orthologs
	2064
	13866
	ENSG00000141736
	ENSMUSG00000062312
	P04626
	P70424
	NM_001005862; NM_001289936; NM_001289937; NM_001289938; NM_004448
	NM_001003817; NM_010152
NP_001005862; NP_001276865; NP_001276866; NP_001276867; NP_004439;
	NP_001369711; NP_001369712; NP_001369713; NP_001369714; NP_001369715; NP_001369716; NP_001369717; NP_001369718; NP_001369719; NP_001369720; NP_001369721; NP_001369722; NP_001369723; NP_001369724; NP_001369725; NP_001369726; NP_001369727; NP_001369728; NP_001369729; NP_001369730; NP_001369731; NP_001369732; NP_001369733; NP_001369734; NP_001369735
	NP_001003817
	Wikidata
View/Edit Human	View/Edit Mouse

Receptor tyrosine-protein kinase erbB-2 is a protein that normally resides in the membranes of cells and is encoded by the ERBB2 gene. ERBB is abbreviated from erythroblastic oncogene B, a gene originally isolated from the avian genome. The human protein is also frequently referred to as HER2 (human epidermal growth factor receptor 2) or CD340 (cluster of differentiation 340).^[5]^[6]^[7]

HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. But contrary to other members of the ERBB family, HER2 does not directly bind ligand. HER2 activation results from heterodimerization with another ERBB member or by homodimerization when HER2 concentration are high, for instance in cancer.^[8] Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years the protein has become an important biomarker and target of therapy for approximately 30% of breast cancer patients.^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000141736 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000062312 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "ERBB2 erb-b2 receptor tyrosine kinase 2 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2016-06-14.
^ "ERBB2". Genetics Home Reference. Archived from the original on December 16, 2012. Retrieved 2016-06-19.
^ Barh D, Gunduz M (2015-01-22). Noninvasive Molecular Markers in Gynecologic Cancers. CRC Press. p. 427. ISBN 978-1-4665-6939-3.
^ Hsu JL, Hung MC (2016). "The role of HER2, EGFR, and other receptor tyrosine kinases in breast cancer". Cancer and Metastasis Reviews. 35 (4): 575–588. doi:10.1007/s10555-016-9649-6. PMC 5215954. PMID 27913999.
^ Cite error: The named reference pmid23320171 was invoked but never defined (see the help page).

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000141736 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000062312 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "ERBB2 erb-b2 receptor tyrosine kinase 2 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2016-06-14.

[6] "ERBB2". Genetics Home Reference. Archived from the original on December 16, 2012. Retrieved 2016-06-19.

[7] Barh D, Gunduz M (2015-01-22). Noninvasive Molecular Markers in Gynecologic Cancers. CRC Press. p. 427. ISBN 978-1-4665-6939-3.

[8] Hsu JL, Hung MC (2016). "The role of HER2, EGFR, and other receptor tyrosine kinases in breast cancer". Cancer and Metastasis Reviews. 35 (4): 575–588. doi:10.1007/s10555-016-9649-6. PMC 5215954. PMID 27913999.

[pmid23320171-9] Cite error: The named reference pmid23320171 was invoked but never defined (see the help page).

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