HLA-DQ1
major histocompatibility complex, class II, DQ1
| |
| Haplotypes | DQA1*0101:DQB1*0501 DQA1*0101:DQB1*0502 DQA1*0102:DQB1*0502 DQA1*0104:DQB1*0503 DQA1*0103:DQB1*0601 DQA1*0102:DQB1*0602 DQA1*0103:DQB1*0603 DQA1*0102:DQB1*0604 DQA1*0102:DQB1*0605 DQA1*0102:DQB1*0609.... |
| Structure | |
| Identifiers | alpha 1 *0101 *0102 *0103 *0104
|
| Symbol(s) | HLA-DQA1 |
| EBI-HLA | DQA1*0101 |
| EBI-HLA | DQA1*0102 Archived 2011-05-15 at the Wayback Machine |
| EBI-HLA | DQA1*0103 |
| EBI-HLA | DQA1*0104 |
| Identifiers | beta 1 *05 or *06
|
| Symbol(s) | HLA-DQB1 |
| EBI-HLA | DQB1*05 |
| EBI-HLA | DQB1*06 |
| Shared data | |
| Locus | chr.6 6p21.31 |
HLA-DQ1 is a serotype that covers a broad range of HLA-DQ haplotypes. Historically it was identified as a DR-like alpha chain called DC1;[1] later, it was among 3 types DQw1 (later DQ1, and split into DQ5 and DQ6), DQw2 and DQw3. Of these three serotyping specificities only DQw1 recognized DQ alpha chain.[2] The serotype is positive in individuals who bear the DQA1*01 alleles. The most frequently found within this group are: DQA1*0101, *0102, *0103, and *0104. In the illustration on the right, DQ1 serotyping antibodies recognizes the DQ α (magenta), where antibodies to DQA1* gene products bind variable regions close to the peptide binding pocket.
- ^ Trowsdale J, Lee J, Carey J, Grosveld F, Bodmer J, Bodmer W (1983). "Sequences related to HLA-DR alpha chain on human chromosome 6: restriction enzyme polymorphism detected with DC alpha chain probes". Proc. Natl. Acad. Sci. U.S.A. 80 (7): 1972–6. Bibcode:1983PNAS...80.1972T. doi:10.1073/pnas.80.7.1972. PMC 393734. PMID 6300884.
- ^ Möller E, Carlsson B, Wallin J (1985). "Implication of structural class II gene polymorphism for the concept of serologic specificities". Immunol. Rev. 85: 107–28. doi:10.1111/j.1600-065X.1985.tb01132.x. PMID 2412948. S2CID 20971131.