Hailey–Hailey disease
| Hailey–Hailey disease | |
|---|---|
| Other names | Familial benign chronic pemphigus |
| Left axilla mild, uninfected Hailey–Hailey lesion | |
| Specialty | Medical genetics |
| Symptoms | Rashes and blisters on the skin, could be painful to the touch with a possibility of acantholysis, erythema and hyperkeratosis. |
| Usual onset | Late teenage years or 30s-40s |
| Duration | Chronic |
| Causes | Mutations in the ATP2C1 gene |
| Risk factors | Family history |
| Named after | Hugh Edward Hailey and William Howard Hailey |
Hailey–Hailey disease (HHD), or familial benign chronic pemphigus[1]: 559 or familial benign pemphigus,[2]: 622 was originally described by the Hailey brothers (Hugh Edward and William Howard) in 1939.[3][4] It is a genetic disorder that causes blisters to form on the skin.
- ^ James WD, Berger T, Elston D (2006). Andrews' Diseases of the Skin: Clinical Dermatology (10th ed.). Philadelphia: Saunders Elsevier. ISBN 978-0-7216-2921-6.
- ^ Freedberg IM, Eisen IZ, Wolff K, Austen F, Goldsmith LA, Katz S (2003). Fitzpatrick's Dermatology in General Medicine (6th ed.). New York: McGraw-Hill, Medical Pub. Division. ISBN 978-0-07-138076-8.
- ^ Gougerot–Hailey–Hailey disease at Whonamedit?
- ^ Hailey H, Hailey H (April 1939). "Familial benign chronic pemphigus". Archives of Dermatology and Syphilology. 39 (4): 679–685. doi:10.1001/archderm.1939.01480220064005.