Howell–Jolly body

See also: Howell-Jolly body-like inclusions

A Howell–Jolly body is a cytopathological finding of basophilic nuclear remnants (clusters of DNA) in circulating erythrocytes. During maturation in the bone marrow, late erythroblasts normally expel their nuclei; but, in some cases, a small portion of DNA remains. The presence of Howell–Jolly bodies usually signifies a damaged or absent spleen, because a healthy spleen would normally filter such erythrocytes.

The Howell–Jolly body is named after William Henry Howell[1] and Justin Marie Jolly.[2][3]

  1. ^ Howell, W. H. (1890). "The life-history of the formed elements of the blood, especially the red blood corpuscles" (PDF). Journal of Morphology. 4 (1). New York: 57–116. doi:10.1002/jmor.1050040105. S2CID 85700639.
  2. ^ synd/1596 at Whonamedit?
  3. ^ Jolly, J (1908). Recherches sur la formation des globules rouges des mammifères (in French). Vol. 58. Paris: Comptes rendus de la Société de Biologie. pp. 528–531.
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