Immune disorder
| Immune disorder | |
|---|---|
| Other names | Autoimmune disease |
| Specialty | Immunology |
An immune disorder is a dysfunction of the immune system.[1] These disorders can be characterized in several different ways:
- By the component(s) of the immune system affected
- By whether the immune system is overactive or underactive
- By whether the condition is congenital or acquired
According to the International Union of Immunological Societies, more than 150 primary immunodeficiency diseases (PIDs) have been characterized.[2] However, the number of acquired immunodeficiencies exceeds the number of PIDs.[3]
It has been suggested that most people have at least one primary immunodeficiency.[4] Due to redundancies in the immune system, though, many of these are never detected.
- ^ Erjavec SO, Gelfman S, Abdelaziz AR, Lee EY, Monga I, Alkelai A, Ionita-Laza I, Petukhova L, Christiano AM (Feb 2022). "Whole exome sequencing in Alopecia Areata identifies rare variants in KRT82". Nat Commun. 13 (1): 800. Bibcode:2022NatCo..13..800E. doi:10.1038/s41467-022-28343-3. PMC 8831607. PMID 35145093.
- ^ Geha RS, Notarangelo LD, Casanova JL, et al. (October 2007). "Primary immunodeficiency diseases: an update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee". J. Allergy Clin. Immunol. 120 (4): 776–94. doi:10.1016/j.jaci.2007.08.053. PMC 2601718. PMID 17952897.
- ^ Kumar A, Teuber SS, Gershwin ME (2006). "Current perspectives on primary immunodeficiency diseases". Clin. Dev. Immunol. 13 (2–4): 223–59. doi:10.1080/17402520600800705. PMC 2270780. PMID 17162365.
- ^ Casanova JL, Abel L (August 2007). "Primary immunodeficiencies: a field in its infancy". Science. 317 (5838): 617–9. Bibcode:2007Sci...317..617C. doi:10.1126/science.1142963. PMID 17673650. S2CID 7287315.