Extracellular matrix
| Extracellular matrix | |
|---|---|
Illustration depicting extracellular matrix (basement membrane and interstitial matrix) in relation to epithelium, endothelium and connective tissue | |
| Details | |
| Identifiers | |
| Latin | matrix extracellularis |
| Acronym(s) | ECM |
| MeSH | D005109 |
| TH | H2.00.03.0.02001 |
| Anatomical terms of microanatomy | |
In biology, the extracellular matrix (ECM),[1][2] also called intercellular matrix (ICM), is a network consisting of extracellular macromolecules and minerals, such as collagen, enzymes, glycoproteins and hydroxyapatite that provide structural and biochemical support to surrounding cells.[3][4][5] Because multicellularity evolved independently in different multicellular lineages, the composition of ECM varies between multicellular structures; however, cell adhesion, cell-to-cell communication and differentiation are common functions of the ECM.[6]
The animal extracellular matrix includes the interstitial matrix and the basement membrane.[7] Interstitial matrix is present between various animal cells (i.e., in the intercellular spaces). Gels of polysaccharides and fibrous proteins fill the interstitial space and act as a compression buffer against the stress placed on the ECM.[8] Basement membranes are sheet-like depositions of ECM on which various epithelial cells rest. Each type of connective tissue in animals has a type of ECM: collagen fibers and bone mineral comprise the ECM of bone tissue; reticular fibers and ground substance comprise the ECM of loose connective tissue; and blood plasma is the ECM of blood.
The plant ECM includes cell wall components, like cellulose, in addition to more complex signaling molecules.[9] Some single-celled organisms adopt multicellular biofilms in which the cells are embedded in an ECM composed primarily of extracellular polymeric substances (EPS).[10]
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- ^ Abedin M, King N (December 2010). "Diverse evolutionary paths to cell adhesion". Trends in Cell Biology. 20 (12): 734–42. Bibcode:2010TCBio..20..734A. doi:10.1016/j.tcb.2010.08.002. PMC 2991404. PMID 20817460.
- ^ Kumar; Abbas; Fausto (2005). Robbins and Cotran: Pathologic Basis of Disease (7th ed.). Philadelphia: Elsevier. ISBN 978-0-7216-0187-8.
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- ^ Brownlee, Colin (October 2002). "Role of the extracellular matrix in cell-cell signalling: paracrine paradigms". Current Opinion in Plant Biology. 5 (5): 396–401. Bibcode:2002COPB....5..396B. doi:10.1016/S1369-5266(02)00286-8. PMID 12183177.
- ^ Kostakioti M, Hadjifrangiskou M, Hultgren SJ (April 2013). "Bacterial biofilms: development, dispersal, and therapeutic strategies in the dawn of the postantibiotic era". Cold Spring Harbor Perspectives in Medicine. 3 (4): a010306. doi:10.1101/cshperspect.a010306. PMC 3683961. PMID 23545571.