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The interleukin-7 receptor is a protein found on the surface of cells. It is made up of two different smaller protein chains - i.e. it is a heterodimer, and consists of two subunits, interleukin-7 receptor-α (CD127) and common-γ chain receptor (CD132).[2][3] The common-γ chain receptors is shared with various cytokines, including interleukin-2, -4, -9, and -15.[4] Interleukin-7 receptor is expressed on various cell types, including naive and memory T cells and many others.
- ^ PDB: 2B5IWang X, Rickert M, Garcia KC (November 2005). "Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors". Science. 310 (5751): 1159–63. Bibcode:2005Sci...310.1159W. doi:10.1126/science.1117893. PMID 16293754. S2CID 85394260.
- ^ Noguchi M, Nakamura Y, Russell SM, Ziegler SF, Tsang M, Cao X, Leonard WJ (December 1993). "Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor". Science. 262 (5141): 1877–80. Bibcode:1993Sci...262.1877N. doi:10.1126/science.8266077. PMID 8266077.
- ^ Kroemer RT, Richards WG (December 1996). "Homology modeling study of the human interleukin-7 receptor complex". Protein Eng. 9 (12): 1135–42. doi:10.1093/protein/9.12.1135. PMID 9010926.
- ^ "IL2 family". Guide to Pharmacology. IUPHAR/BPS. Retrieved 21 August 2015.