Isosorbide

Isosorbide
Clinical data
Trade names	Ismotic, Isobide, others
License data	US DailyMed: Isosorbide;
Identifiers
CompTox Dashboard (EPA)	DTXSID5046196 ;
ECHA InfoCard	100.010.449

Isosorbide
Names
	Preferred IUPAC name (3R,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diol
	Other names D-Isosorbide; 1,4:3,6-Dianhydro-D-sorbitol; 1,4-Dianhydrosorbitol
Identifiers
CAS Number	652-67-5 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:6060;
ChEMBL	ChEMBL1200660 ;
ChemSpider	12077 ;
DrugBank	DB09401;
ECHA InfoCard	100.010.449
KEGG	D00347 ;
PubChem CID	12597;
UNII	WXR179L51S ;
CompTox Dashboard (EPA)	DTXSID5046196 ;
	InChI InChI=1S/C6H10O4/c7-3-1-9-6-4(8)2-10-5(3)6/h3-8H,1-2H2/t3-,4+,5-,6-/m1/s1 Key: KLDXJTOLSGUMSJ-JGWLITMVSA-N ; InChI=1/C6H10O4/c7-3-1-9-6-4(8)2-10-5(3)6/h3-8H,1-2H2/t3-,4+,5-,6-/m1/s1 Key: KLDXJTOLSGUMSJ-JGWLITMVBP;
	SMILES O[C@@H]1[C@H]2OC[C@@H](O)[C@H]2OC1;
Properties
Chemical formula	C6H10O4
Molar mass	146.142 g·mol−1
Appearance	Highly hygroscopic white flakes
Density	1.30 at 25 °C
Melting point	62.5 to 63 °C (144.5 to 145.4 °F; 335.6 to 336.1 K)
Boiling point	160 °C (320 °F; 433 K) at 10 mmHg
Solubility in water	in water (>850 g/L), alcohols and ketones
Pharmacology
ATC code	None
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Isosorbide is a bicyclic chemical compound from the group of diols and the oxygen-containing heterocycles, containing two fused furan rings. The starting material for isosorbide is D-sorbitol, which is obtained by catalytic hydrogenation of D-glucose, which is in turn produced by hydrolysis of starch. Isosorbide is discussed as a plant-based platform chemical from which biodegradable derivatives of various functionality can be obtained.

In 2022, it was the 119th most commonly prescribed medication in the United States, with more than 5 million prescriptions.^[1]^[2]

^ "The Top 300 of 2022". ClinCalc. Archived from the original on 30 August 2024. Retrieved 30 August 2024.
^ "Isosorbide Drug Usage Statistics, United States, 2013 - 2022". ClinCalc. Retrieved 30 August 2024.

[1] "The Top 300 of 2022". ClinCalc. Archived from the original on 30 August 2024. Retrieved 30 August 2024.

[2] "Isosorbide Drug Usage Statistics, United States, 2013 - 2022". ClinCalc. Retrieved 30 August 2024.

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