Kavalactone

Kavalactones are a class of lactone compounds found in kava roots and Alpinia zerumbet (shell ginger)[1] and in several Gymnopilus, Phellinus and Inonotus fungi.[2] Some kavalactones are bioactive. They are responsible for the psychoactive, analgesic, euphoric and sedative effects of kava.[3][4]

  1. ^ Tadiparthi, Krishnaji; Anand, Pragya (2021). "A Review on Synthetic Approaches towards Kavalactones". Synthesis. 53 (19): 3469–3484. doi:10.1055/s-0040-1706044. S2CID 236392304.
  2. ^ Hatfield, G. M.; Brady, L. R. (1969). "Occurrence of bis-noryangonin in Gymnopilus spectabilis". Journal of Pharmaceutical Sciences. 58 (10): 1298–1299. Bibcode:1969JPhmS..58.1298H. doi:10.1002/jps.2600581039. PMID 5388695.
  3. ^ You, Hualin; He, Min; Pan, Di; Fang, Guanqin; Chen, Yan; Zhang, Xu; Shen, Xiangchun; Zhang, Nenling (2022). "Kavalactones isolated from Alpinia zerumbet (Pers.) Burtt. Et Smith with protective effects against human umbilical vein endothelial cell damage induced by high glucose". Natural Product Research. 36 (22): 5740–5746. doi:10.1080/14786419.2021.2023866. PMID 34989299. S2CID 245771677.
  4. ^ James M. Mathews; Amy S. Etheridge; Sherry R. Black (2002). "Inhibition of Human Cytochrome P450 Activities by Kava Extract and Kavalactones". Drug Metabolism and Disposition. 30 (11): 1153–1157. doi:10.1124/dmd.30.11.1153. PMID 12386118.
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