Ketoprofen

Ketoprofen
Clinical data
Trade names	Oruvail, others
AHFS/Drugs.com	Monograph
MedlinePlus	a686014
License data	US DailyMed: Ketoprofen;
Pregnancy; category	AU: C;
Routes of; administration	By mouth, topical, intravenous
ATC code	M01AE03 (WHO) M01AE53 (WHO), M02AA10 (WHO);
Legal status
Legal status	AU: S3 (Pharmacist only) / S4; CA: ℞-only; US: ℞-only; Rx-only & OTC;
Pharmacokinetic data
Protein binding	99%
Elimination half-life	2–2.5 hours
Identifiers
	IUPAC name (RS)-2-(3-benzoylphenyl)propanoic acid;
CAS Number	22071-15-4 ;
PubChem CID	3825;
IUPHAR/BPS	4795;
DrugBank	DB01009 ;
ChemSpider	3693 ;
UNII	90Y4QC304K;
KEGG	D00132 ;
ChEBI	CHEBI:6128 ;
ChEMBL	ChEMBL571 ;
CompTox Dashboard (EPA)	DTXSID6020771 ;
ECHA InfoCard	100.040.676
Chemical and physical data
Formula	C16H14O3
Molar mass	254.285 g·mol−1
3D model (JSmol)	Interactive image;
Chirality	Racemic mixture
	SMILES CC(c1cccc(c1)C(=O)c2ccccc2)C(=O)O;
	InChI InChI=1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19) ; Key:DKYWVDODHFEZIM-UHFFFAOYSA-N ;
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Ketoprofen is one of the propionic acid class of nonsteroidal anti-inflammatory drugs (NSAID) with analgesic and antipyretic effects.^[2] It acts by inhibiting the body's production of prostaglandin.

It was patented in 1967 and approved for medical use in 1980.^[3]

^ "Health product highlights 2021: Annexes of products approved in 2021". Health Canada. 3 August 2022. Retrieved 25 March 2024.
^ Kantor TG (1986). "Ketoprofen: a review of its pharmacologic and clinical properties". Pharmacotherapy. 6 (3): 93–103. doi:10.1002/j.1875-9114.1986.tb03459.x. PMID 3526298. S2CID 25309841.
^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 520. ISBN 9783527607495.