Laryngeal papillomatosis

Laryngeal papillomatosis
Other namesAdult papillomatosis, Juvenile papillomatosis, Recurrent respiratory papillomatosis (RRP), Squamous cell papillomatosis, Nonkeratinized papillomatosis
Volumetric CT rendering of multiple tracheal papilloma (arrow)
SpecialtyOtorhinolaryngology 
ComplicationsSquamous cell carcinoma
CausesHPV infection

Laryngeal papillomatosis, also known as recurrent respiratory papillomatosis (RRP) or glottal papillomatosis, is a rare medical condition in which benign tumors (papilloma) form along the aerodigestive tract.[1][2] There are two variants based on the age of onset: juvenile and adult laryngeal papillomatosis.[3] The tumors are caused by human papillomavirus (HPV) infection of the throat. The tumors may lead to narrowing of the airway, which may cause vocal changes or airway obstruction.[4][5] Laryngeal papillomatosis is initially diagnosed through indirect laryngoscopy upon observation of growths on the larynx and can be confirmed through a biopsy.[6][7][8] Treatment for laryngeal papillomatosis aims to remove the papillomas and limit their recurrence.[9] Due to the recurrent nature of the virus, repeated treatments are usually needed.[7][9][2][10] Laryngeal papillomatosis is primarily treated surgically, though supplemental nonsurgical and/or medical treatments may be considered in some cases.[7][10] The evolution of laryngeal papillomatosis is highly variable.[4][1] Though total recovery may be observed, it is often persistent despite treatment.[11][8][1] The number of new cases of laryngeal papillomatosis is approximately 4.3 cases per 100,000 children and 1.8 cases per 100,000 adults annually.[1][6][7][12]

  1. ^ a b c d Cite error: The named reference IARC was invoked but never defined (see the help page).
  2. ^ a b Cite error: The named reference Carifi2015 was invoked but never defined (see the help page).
  3. ^ Cite error: The named reference Taliercio2015 was invoked but never defined (see the help page).
  4. ^ a b Mehta AC, Jain P, Prasoon G, Gildea TR (2016). Diseases of the central airways: a clinical guide. Springer. pp. 215–218. ISBN 9783319298283. OCLC 945577007.
  5. ^ Cite error: The named reference Venkatesan2012 was invoked but never defined (see the help page).
  6. ^ a b Cite error: The named reference GrimesBook2014 was invoked but never defined (see the help page).
  7. ^ a b c d Cite error: The named reference Fortes2017 was invoked but never defined (see the help page).
  8. ^ a b "Recurrent Respiratory Papillomatosis or Laryngeal Papillomatosis". NIDCD. 2015-08-18. Retrieved 2017-10-21.
  9. ^ a b Cite error: The named reference Alfano2014 was invoked but never defined (see the help page).
  10. ^ a b Cite error: The named reference Avelino2013 was invoked but never defined (see the help page).
  11. ^ Cite error: The named reference :0 was invoked but never defined (see the help page).
  12. ^ Cite error: The named reference ColtonBook2011 was invoked but never defined (see the help page).
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