Leser–Trélat sign

The Leser–Trélat sign is the explosive onset of multiple seborrheic keratoses[1] (many pigmented skin lesions),[2][3] often with an inflammatory base. This can be a sign of internal malignancy as part of a paraneoplastic syndrome. In addition to the development of new lesions, preexisting ones frequently increase in size and become symptomatic.

  1. ^ Schwartz RA (July 1996). "Sign of Leser-Trélat". J. Am. Acad. Dermatol. 35 (1): 88–95. doi:10.1016/S0190-9622(96)90502-2. PMID 8682971.
  2. ^ James, William D.; Elston, Dirk; Treat, James R.; Rosenbach, Misha A.; Neuhaus, Isaac (2020). "29. Epidermal nevi, neoplasms, and cysts". Andrews' Diseases of the Skin: Clinical Dermatology (13th ed.). Edinburgh: Elsevier. p. 641. ISBN 978-0-323-54753-6.
  3. ^ Schwartz, Robert A (2024-05-16). "Sign of Leser-Trelat: Background, Pathophysiology, Etiology". Medscape Reference. Retrieved 2024-08-08.
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