Limbal stem cell

Limbal stem cell
Clinical data
Trade names	Holoclar
Other names	ex vivo expanded autologous human corneal epithelial cells containing stem cells
AHFS/Drugs.com	UK Drug Information
ATC code	S01XA19 (WHO) ;
Legal status
Legal status	EU: Rx-only;

Limbal stem cells, also known as corneal epithelial stem cells, are unipotent stem cells located in the basal epithelial layer of the corneal limbus. They form the border between the cornea and the sclera. Characteristics of limbal stem cells include a slow turnover rate, high proliferative potential, clonogenicity, expression of stem cell markers, as well as the ability to regenerate the entire corneal epithelium. Limbal stem cell proliferation has the role of maintaining the cornea; for example, by replacing cells that are lost via tears. Additionally, these cells also prevent the conjunctival epithelial cells from migrating onto the surface of the cornea.^[2]

^ Cite error: The named reference Holoclar EPAR was invoked but never defined (see the help page).
^ Schlötzer-Schrehardt U, Kruse FE (September 2005). "Identification and characterization of limbal stem cells". Experimental Eye Research. 81 (3): 247–264. doi:10.1016/j.exer.2005.02.016. PMID 16051216.

[Holoclar_EPAR-1] Cite error: The named reference Holoclar EPAR was invoked but never defined (see the help page).

[2] Schlötzer-Schrehardt U, Kruse FE (September 2005). "Identification and characterization of limbal stem cells". Experimental Eye Research. 81 (3): 247–264. doi:10.1016/j.exer.2005.02.016. PMID 16051216.

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