Liothyronine

Liothyronine
Clinical data
Trade names	Cytomel, Tertroxin, others
AHFS/Drugs.com	Monograph
MedlinePlus	a682462
License data	US DailyMed: Liothyronine;
Routes of; administration	By mouth, intravenous
ATC code	H03AA02 (WHO) ;
Legal status
Legal status	CA: ℞-only; UK: POM (Prescription only);
Pharmacokinetic data
Protein binding	99.7%
Elimination half-life	2.5 days
Identifiers
	IUPAC name (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid;
CAS Number	6893-02-3 ;
PubChem CID	5920;
IUPHAR/BPS	2634;
DrugBank	DB00279 ;
ChemSpider	5707 ;
UNII	06LU7C9H1V;
KEGG	D08128;
ChEBI	CHEBI:18258 ;
ChEMBL	ChEMBL1544 ;
PDB ligand	T3 (PDBe, RCSB PDB);
CompTox Dashboard (EPA)	DTXSID8047505 ;
ECHA InfoCard	100.000.203
Chemical and physical data
Formula	C15H12I3NO4
Molar mass	650.977 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1=CC(=C(C=C1OC2=C(C=C(C=C2I)C[C@@H](C(=O)O)N)I)I)O;
	InChI InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 ; Key:AUYYCJSJGJYCDS-LBPRGKRZSA-N ;
	(what is this?) (verify)

Liothyronine is a manufactured form of the thyroid hormone triiodothyronine (T₃).^[2] It is most commonly used to treat hypothyroidism and myxedema coma.^[2] It can be taken by mouth or by injection into a vein.^[2]

Side effects may occur from excessive doses.^[2] This may include weight loss, fever, headache, anxiety, trouble sleeping, arrhythmias, and heart failure.^[2] Use in pregnancy and breastfeeding is generally safe.^[3]^[2]

Liothyronine was approved for medical use in 1956.^[2] It is available as a generic medication.^[3] In 2022, it was the 204th most commonly prescribed medication in the United States, with more than 1 million prescriptions.^[4]^[5]

^ "Cytomel Product information". Health Canada. 20 March 2013. Retrieved 9 January 2025.
^ ^a ^b ^c ^d ^e ^f ^g "Liothyronine Sodium Monograph for Professionals". Drugs.com. Retrieved 27 February 2019.
^ ^a ^b British National Formulary: BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 757. ISBN 9780857113382.
^ "The Top 300 of 2022". ClinCalc. Archived from the original on 30 August 2024. Retrieved 30 August 2024.
^ "Liothyronine Drug Usage Statistics, United States, 2013 - 2022". ClinCalc. Retrieved 30 August 2024.

[1] "Cytomel Product information". Health Canada. 20 March 2013. Retrieved 9 January 2025.

[AHFS2019-2] ^ ^a ^b ^c ^d ^e ^f ^g "Liothyronine Sodium Monograph for Professionals". Drugs.com. Retrieved 27 February 2019.

[BNF76-3] British National Formulary: BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 757. ISBN 9780857113382.

[Top_300_of_2022-4] "The Top 300 of 2022". ClinCalc. Archived from the original on 30 August 2024. Retrieved 30 August 2024.

[5] "Liothyronine Drug Usage Statistics, United States, 2013 - 2022". ClinCalc. Retrieved 30 August 2024.

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