Lisinopril
Chemical structure of lisinopril | |
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| Pronunciation | /laɪˈsɪnəprɪl/ ⓘ, ly-SIN-ə-pril |
| Trade names | Prinivil,[1] Zestril,[2] Qbrelis,[3] Dapril,[4] others[5] |
| Other names | (2S)-1-[(2S)-6-amino-2-{[(1S)-1-carboxy-3-phenylpropyl]amino}hexanoyl]pyrrolidine-2-carboxylic acid |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a692051 |
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| Routes of administration | Oral |
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| Bioavailability | approx. 25%, but a wide range between individuals (6 to 60%) |
| Protein binding | 0 |
| Metabolism | None |
| Elimination half-life | 12 hours |
| Excretion | Eliminated unchanged in urine |
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| ECHA InfoCard | 100.071.332 |
| Chemical and physical data | |
| Formula | C21H31N3O5 |
| Molar mass | 405.495 g·mol−1 |
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Lisinopril is a medication belonging to the drug class of angiotensin-converting enzyme (ACE) inhibitors and is used to treat hypertension (high blood pressure), heart failure, and heart attacks.[7] For high blood pressure it is usually a first-line treatment. It is also used to prevent kidney problems in people with diabetes mellitus.[7] Lisinopril is taken orally (swallowed by mouth).[7] Full effect may take up to four weeks to occur.[7]
Common side effects include headache, dizziness, feeling tired, cough, nausea, and rash.[7] Serious side effects may include low blood pressure, liver problems, hyperkalemia (high blood potassium), and angioedema.[7] Use is not recommended during the entire duration of pregnancy as it may harm the baby.[7] Lisinopril works by inhibiting the renin–angiotensin–aldosterone system.[7]
Lisinopril was patented in 1978 and approved for medical use in the United States in 1987.[7][10] It is available as a generic medication.[7] In 2022, it was the third most commonly prescribed medication in the United States, with more than 82 million prescriptions.[11][12] It is available in combination with amlodipine (as lisinopril/amlodipine) and in combination with hydrochlorothiazide (as lisinopril/hydrochlorothiazide).
- ^ a b Cite error: The named reference
Prinivil FDA Labelwas invoked but never defined (see the help page). - ^ a b "Zestril- lisinopril tablet". DailyMed. 31 October 2019. Retrieved 5 August 2020.
- ^ a b "Qbrelis- lisinopril solution". DailyMed. 31 March 2020. Retrieved 5 August 2020.
- ^ "Dapril". Drugs.com. Drugsite Trust. Retrieved 13 August 2021.
- ^ Cite error: The named reference
Brandswas invoked but never defined (see the help page). - ^ a b "Lisinopril Use During Pregnancy". Drugs.com. 22 October 2019. Retrieved 27 February 2020.
- ^ a b c d e f g h i j k "Lisinopril Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 23 December 2018.
- ^ "Product monograph brand safety updates". Health Canada. February 2024. Retrieved 24 March 2024.
- ^ "Summary of Product Characteristics (SmPC) – (emc)". Lisinopril 10mg Tablet. 13 November 2019. Archived from the original on 28 February 2020. Retrieved 27 February 2020.
- ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 467. ISBN 978-3-527-60749-5.
- ^ "The Top 300 of 2022". ClinCalc. Archived from the original on 30 August 2024. Retrieved 30 August 2024.
- ^ "Lisinopril Drug Usage Statistics, United States, 2013 - 2022". ClinCalc. Retrieved 30 August 2024.