Loprazolam

Loprazolam
Clinical data
Trade names	Dormonoct, Havlane, Sonin, Somnovit, others
AHFS/Drugs.com	International Drug Names
Pregnancy; category	D;
Routes of; administration	Oral
ATC code	N05CD11 (WHO) ;
Legal status
Legal status	BR: Class B1 (Psychoactive drugs); CA: Schedule IV; DE: Prescription only (Anlage III for higher doses); US: Schedule IV;
Pharmacokinetic data
Metabolism	Hepatic
Elimination half-life	6–12 hours
Excretion	Renal
Identifiers
	IUPAC name (2Z)-6-(2-Chlorophenyl)-2-[(4-methyl-1-piperazinyl)methylene]-8-nitro-2,4-dihydro-1H-imidazo[1,2-a][1,4]benzodiazepin-1-one;
CAS Number	61197-73-7 ;
PubChem CID	3033860;
DrugBank	DB13643 ;
ChemSpider	2298440 ;
UNII	759N8462G8;
KEGG	D07326 ;
CompTox Dashboard (EPA)	DTXSID30894873 ;
ECHA InfoCard	100.293.781
Chemical and physical data
Formula	C23H21ClN6O3
Molar mass	464.91 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES [O-][N+](=O)c1cc4c(cc1)N/2C(=O)C(\N=C\2C/N=C4/c3ccccc3Cl)=C\N5CCN(C)CC5;
	InChI InChI=1S/C23H21ClN6O3/c1-27-8-10-28(11-9-27)14-19-23(31)29-20-7-6-15(30(32)33)12-17(20)22(25-13-21(29)26-19)16-4-2-3-5-18(16)24/h2-7,12,14H,8-11,13H2,1H3/b19-14- ; Key:UTEFBSAVJNEPTR-RGEXLXHISA-N ;
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Loprazolam (triazulenone) marketed under many brand names is a benzodiazepine medication. It possesses anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. It is licensed and marketed for the short-term treatment of moderately-severe insomnia.

It was patented in 1975 and came into medical use in 1983.^[2]

^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 539. ISBN 9783527607495.