Lumefantrine

Lumefantrine
Clinical data
Other names	benflumetol
AHFS/Drugs.com	International Drug Names
MedlinePlus	a609024
Routes of; administration	Oral
ATC code	P01BF01 (WHO) (combination with artemether);
Legal status
Legal status	US: C; EU: Rx-only;
Pharmacokinetic data
Protein binding	99.7%
Metabolites	desbutyl-lumefantrine
Elimination half-life	3-6 days
Identifiers
	IUPAC name 2-(Dibutylamino)-1-[(9Z)-2,7-dichloro-9-(4-chlorobenzylidene)-9H-fluoren-4-yl]ethanol;
CAS Number	82186-77-4 ; 120583-70-2;
PubChem CID	6437380;
DrugBank	DB06708 ;
ChemSpider	4941944 ;
UNII	F38R0JR742; ZUV4B00D9P;
KEGG	D03821 ;
ChEBI	CHEBI:156095 ;
ChEMBL	ChEMBL38827 ;
CompTox Dashboard (EPA)	DTXSID3046663 ;
ECHA InfoCard	100.133.797
Chemical and physical data
Formula	C30H32Cl3NO
Molar mass	528.94 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	130 to 132 °C (266 to 270 °F)
Solubility in water	30.9ng/mL
	SMILES Clc1ccc(cc1)\C=C3\c4c(c2c(cc(Cl)cc23)C(O)CN(CCCC)CCCC)ccc(Cl)c4;
	InChI InChI=1S/C30H32Cl3NO/c1-3-5-13-34(14-6-4-2)19-29(35)28-18-23(33)17-27-25(15-20-7-9-21(31)10-8-20)26-16-22(32)11-12-24(26)30(27)28/h7-12,15-18,29,35H,3-6,13-14,19H2,1-2H3/b25-15- ; Key:DYLGFOYVTXJFJP-MYYYXRDXSA-N ;
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Lumefantrine (or benflumetol) is an antimalarial drug. It is only used in combination with artemether. The term "co-artemether" is sometimes used to describe this combination.^[1] Lumefantrine has a much longer half-life compared to artemether (3-6 days vs. 2 hours^[2]), and is therefore thought to clear any residual parasites that remain after combination treatment.^[3]

^ Toovey S, Jamieson A, Nettleton G (August 2003). "Successful co-artemether (artemether-lumefantrine) clearance of falciparum malaria in a patient with severe cholera in Mozambique". Travel Medicine and Infectious Disease. 1 (3): 177–179. doi:10.1016/j.tmaid.2003.09.002. PMID 17291911.
^ "Coartem - Highlights of prescribing information" (PDF). Novartis. August 2019. Retrieved 26 February 2025.
^ White NJ, van Vugt M, Ezzet F (August 1999). "Clinical pharmacokinetics and pharmacodynamics and pharmacodynamics of artemether-lumefantrine". Clinical Pharmacokinetics. 37 (2): 105–125. doi:10.2165/00003088-199937020-00002. PMID 10496300. S2CID 72714420.

[pmid17291911-1] Toovey S, Jamieson A, Nettleton G (August 2003). "Successful co-artemether (artemether-lumefantrine) clearance of falciparum malaria in a patient with severe cholera in Mozambique". Travel Medicine and Infectious Disease. 1 (3): 177–179. doi:10.1016/j.tmaid.2003.09.002. PMID 17291911.

[:0-2] "Coartem - Highlights of prescribing information" (PDF). Novartis. August 2019. Retrieved 26 February 2025.

[Whitevan_Vugt1999-3] White NJ, van Vugt M, Ezzet F (August 1999). "Clinical pharmacokinetics and pharmacodynamics and pharmacodynamics of artemether-lumefantrine". Clinical Pharmacokinetics. 37 (2): 105–125. doi:10.2165/00003088-199937020-00002. PMID 10496300. S2CID 72714420.

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