Lupus nephritis
| Lupus nephritis | |
|---|---|
| Other names | SLE nephritis[1] |
| Micrograph of diffuse proliferative lupus nephritis showing increased mesangial matrix and mesangial hypercellularity. Kidney biopsy. PAS stain. | |
| Specialty | Nephrology, rheumatology |
| Symptoms | Joint pain or swelling[2] |
| Causes | Complication of systemic lupus erythematosus.[3] |
| Diagnostic method | Complement levels, Urinalysis[3] |
| Treatment | Corticosteroids may be used[3] |
Lupus nephritis is an inflammation of the kidneys caused by systemic lupus erythematosus (SLE) and childhood-onset systemic lupus erythematosus which is a more severe form of SLE that develops in children up to 18 years old; both are autoimmune diseases.[3][4] It is a type of glomerulonephritis in which the glomeruli become inflamed. Since it is a result of SLE, this type of glomerulonephritis is said to be secondary, and has a different pattern and outcome from conditions with a primary cause originating in the kidney.[5][2] The diagnosis of lupus nephritis depends on blood tests, urinalysis, X-rays, ultrasound scans of the kidneys, and a kidney biopsy. On urinalysis, a nephritic picture is found and red blood cell casts, red blood cells and proteinuria is found.
- ^ Ponticelli, C.; Moroni, G. (2005-01-01). "Renal transplantation in lupus nephritis". Lupus. 14 (1): 95–98. doi:10.1191/0961203305lu2067oa. ISSN 0961-2033. PMID 15732296. S2CID 36968488.
- ^ a b "Lupus Nephritis". www.niddk.nih.gov. Archived from the original on June 14, 2015. Retrieved 2015-10-31.
- ^ a b c d "Lupus nephritis: MedlinePlus Medical Encyclopedia". www.nlm.nih.gov. Retrieved 2015-10-31.
- ^ Lee WF, Fan WL, Tseng MH, Yang HY, Huang JL, Wu CY (August 2022). "Characteristics and genetic analysis of patients suspected with early-onset systemic lupus erythematosus". Pediatric Rheumatology Online Journal. 20 (1): 68. doi:10.1186/s12969-022-00722-6. PMC 9375402. PMID 35964089.
- ^ Saxena, Ramesh; Mahajan, Tina; Mohan, Chandra (2011-01-01). "Lupus nephritis: current update". Arthritis Research & Therapy. 13 (5): 240. doi:10.1186/ar3378. ISSN 1478-6354. PMC 3308062. PMID 22078716.