Marchiafava–Bignami disease
| Marchiafava–Bignami disease | |
|---|---|
| This condition affects the corpus callosum | |
| Specialty | Neurology |
Marchiafava–Bignami disease (MBD) is a progressive neurological disease of alcohol use disorder or malnutrition, characterized by corpus callosum demyelination and necrosis and subsequent atrophy. The disease was first described in 1903 by the Italian pathologists Amico Bignami and Ettore Marchiafava in an Italian Chianti drinker.[1][2] In this autopsy, Marchiafava and Bignami noticed that the middle two-thirds of the corpus callosum were necrotic. It presents in three forms: acute, subacute, and chronic.[3] It is very difficult to diagnose and there is no specific treatment. Until 2008 only around 300 cases had been reported.[4] If the condition is detected early enough, most patients survive.
- ^ synd/2922 at Whonamedit?
- ^ E. Marchiafava, A. Bignami. Sopra un'alterazione del corpo calloso osservata da sogetti alcoolisti. Rivista di patologia nervosa e mentale, 1903, 8 (12): 544–549.
- ^ Singer, Emad; Bhatt, Kinal; Prashad, Adesh; Rudman, Larri; Gadelmoula, Islam; Michel, George (2023). "Diagnosis and Management of Marchiafava-Bignami Disease, a Rare Neurological Complication of Long-term Alcohol Abuse". Discoveries (Craiova, Romania). 11 (2): e168. doi:10.15190/d.2023.7. ISSN 2359-7232. PMC 10406581. PMID 37559750.
- ^ "Marchiafava-Bignami Syndrome. MBD information". patient.info. Retrieved 2017-12-13.