McLeod syndrome

This article is about the genetic disease of the blood. For the lung disease, see Swyer-James syndrome.
McLeod syndrome
Other namesMcLeod phenomenon
McLeod syndrome is inherited in an X-linked recessive manner.[1]

McLeod syndrome (/məˈklaʊd/ mə-KLOWD) is an X-linked recessive genetic disorder that may affect the blood, brain, peripheral nerves, muscle, and heart. It is caused by a variety of recessively inherited mutations in the XK gene on the X chromosome. The gene is responsible for producing the Kx protein, a secondary supportive protein for the Kell antigen on the red blood cell surface.

  1. ^ Reference, Genetics Home. "McLeod neuroacanthocytosis syndrome". Genetics Home Reference. Retrieved 1 November 2017.
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