Mecillinam
| Clinical data | |
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| Trade names | Coactin, Leo, Selexid, Selexidin |
| AHFS/Drugs.com | International Drug Names |
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| Routes of administration | Intravenous, intramuscular |
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| Pharmacokinetic data | |
| Bioavailability | Negligible |
| Protein binding | 5 to 10% |
| Metabolism | Some hepatic metabolism |
| Elimination half-life | 1 to 3 hours |
| Excretion | Renal and biliary, mostly unchanged |
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IUPAC name
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| ECHA InfoCard | 100.046.601 |
| Chemical and physical data | |
| Formula | C15H23N3O3S |
| Molar mass | 325.43 g·mol−1 |
| 3D model (JSmol) | |
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Mecillinam (INN) or amdinocillin (USAN) is an extended-spectrum penicillin antibiotic of the amidinopenicillin class that binds specifically to penicillin binding protein 2 (PBP2),[2] and is only considered to be active against Gram-negative bacteria. It is used primarily in the treatment of urinary tract infections, and has also been used to treat typhoid and paratyphoid fever.[3][4] Because mecillinam has very low oral bioavailability, an orally active prodrug was developed: pivmecillinam.
- ^ Nicolle LE (August 2000). "Pivmecillinam in the treatment of urinary tract infections". The Journal of Antimicrobial Chemotherapy. 46 (Suppl A): 35–39. doi:10.1093/jac/46.suppl_1.35. PMID 10969050.
- ^ Neu HC (1985). "Amdinocillin: a novel penicillin. Antibacterial activity, pharmacology and clinical use". Pharmacotherapy. 5 (1): 1–10. doi:10.1002/j.1875-9114.1985.tb04448.x. PMID 3885172. S2CID 46561080.
- ^ Clarke PD, Geddes AM, McGhie D, Wall JC (July 1976). "Mecillinam: a new antibiotic for enteric fever". British Medical Journal. 2 (6026): 14–15. doi:10.1136/bmj.2.6026.14. PMC 1687648. PMID 820402.
- ^ Geddes AM, Clarke PD (July 1977). "The treatment of enteric fever with mecillinam". The Journal of Antimicrobial Chemotherapy. 3 (Suppl B): 101–102. doi:10.1093/jac/3.suppl_b.101. PMID 408321.