Meropenem/vaborbactam
| Combination of | |
|---|---|
| Meropenem | Beta-lactam antibiotic |
| Vaborbactam | Beta-lactamase inhibitor |
| Clinical data | |
| Trade names | Vabomere, Vaborem, others |
| AHFS/Drugs.com | Monograph |
| License data | |
| Routes of administration | Intravenous |
| ATC code | |
| Legal status | |
| Legal status | |
| Identifiers | |
| CAS Number | |
| KEGG | |
Meropenem/vaborbactam, sold under the brand name Vabomere among others, is a combination medication used to treat complicated urinary tract infections, complicated abdominal infections, and hospital-acquired pneumonia.[2][3][4] It contains meropenem, a beta-lactam antibiotic; and vaborbactam, a beta-lactamase inhibitor.[4] It is given by injection into a vein.[4]
Common side effects include headache, inflammation at the site of injection, nausea, diarrhea, liver inflammation, and low blood potassium.[4] Severe side effects may include anaphylaxis, seizures, and Clostridioides difficile-associated diarrhea.[4] It is unclear if use during pregnancy is safe.[5] Meropenem works by blocking the construction of the bacterial cell wall while vaborbactam blocks the breakdown of meropenem by some beta-lactamases.[4]
The combination was approved for medical use in the United States in 2017,[6] in the European Union in 2018,[4][3] and in Canada in December 2024.[7] It is on the World Health Organization's List of Essential Medicines.[8]
- ^ "Summary Basis of Decision for Vabomere". Drug and Health Products Portal. 4 April 2025. Retrieved 10 July 2025.
- ^ a b "Vabomere- meropenem-vaborbactam injection, powder, for solution". DailyMed. 19 October 2023. Retrieved 26 July 2024.
- ^ a b c "Vaborem EPAR". European Medicines Agency. 24 September 2018. Retrieved 6 November 2019.
- ^ a b c d e f g "Vabomere (combination) Monograph for Professionals". Drugs.com. Retrieved 6 November 2019.
- ^ "Meropenem / vaborbactam (Vabomere) Use During Pregnancy". Drugs.com. Retrieved 6 November 2019.
- ^ Cite error: The named reference
FDA PR 20170829was invoked but never defined (see the help page). - ^ "Register of Innovative Drugs". Health Canada. 13 January 2025. Retrieved 15 January 2025.
- ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.