Mesenchymal stem cell
| Mesenchymal stem cell | |
|---|---|
Transmission electron micrograph of a mesenchymal stem cell displaying typical ultrastructural characteristics | |
| Details | |
| Identifiers | |
| Latin | cellula mesenchymatica praecursoria |
| MeSH | D059630 |
| TH | H2.00.01.0.00008 |
| Anatomical terms of microanatomy | |
Mesenchymal stem cells (MSCs), also known as mesenchymal stromal cells or medicinal signaling cells, are multipotent stromal cells that can differentiate into a variety of cell types, including osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes (fat cells which give rise to marrow adipose tissue).[1][2][3][4]
The primary function of MSCs is to respond to injury and infection by secreting and recruiting a range of biological factors, as well as modulating inflammatory processes to facilitate tissue repair and regeneration. Extensive research interest has led to more than 80,000 peer-reviewed papers on MSCs.[5]
- ^ Tonk CH, Witzler M, Schulze M, Tobiasch E (2020). "Mesenchymal Stem Cells". In Brand-Saberi B (ed.). Essential Current Concepts in Stem Cell Biology. Learning Materials in Biosciences. Cham: Springer International Publishing. pp. 21–39. doi:10.1007/978-3-030-33923-4_2. ISBN 978-3-030-33923-4. S2CID 214523766.
- ^ Ankrum JA, Ong JF, Karp JM (March 2014). "Mesenchymal stem cells: immune evasive, not immune privileged". Nature Biotechnology. 32 (3): 252–60. doi:10.1038/nbt.2816. PMC 4320647. PMID 24561556.
- ^ Mahla RS (2016). "Stem Cells Applications in Regenerative Medicine and Disease Therapeutics". International Journal of Cell Biology. 2016: 6940283. doi:10.1155/2016/6940283. PMC 4969512. PMID 27516776.
- ^ Caplan AI (June 2017). "Mesenchymal Stem Cells: Time to Change the Name!". Stem Cells Translational Medicine. 6 (6): 1445–1451. doi:10.1002/sctm.17-0051. PMC 5689741. PMID 28452204.
- ^ Li Z, Hu X, Zhong JF (2019). "Mesenchymal Stem Cells: Characteristics, Function, and Application". Stem Cells Int. 2019: 8106818. doi:10.1155/2019/8106818. PMC 6431372. PMID 30956675.