Mianserin

Mianserin
Clinical data
Trade names	Tolvon, others
Other names	Mianserin hydrochloride; Org GB 94
Pregnancy; category	AU: B2;
Routes of; administration	By mouth
ATC code	N06AX03 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); BR: Class C1 (Other controlled substances); UK: POM (Prescription only);
Pharmacokinetic data
Bioavailability	20–30%
Protein binding	95%
Metabolism	Liver (CYP2D6; via aromatic hydroxylation, N-oxidation, N-demethylation)
Elimination half-life	21–61 hours
Excretion	Urine: 4–7%; Feces: 14–28%
Identifiers
	IUPAC name (±)-2-methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine;
CAS Number	24219-97-4 ; 21535-47-7 (hydrochloride); 51152-88-6 ((S)-isomer);
PubChem CID	4184;
IUPHAR/BPS	135;
DrugBank	DB06148 ;
ChemSpider	4040 ;
UNII	250PJI13LM;
KEGG	D08216 ;
ChEBI	CHEBI:51137 ;
ChEMBL	ChEMBL6437 ;
CompTox Dashboard (EPA)	DTXSID6023317 ;
ECHA InfoCard	100.041.884
Chemical and physical data
Formula	C18H20N2
Molar mass	264.372 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c42c(N3C(c1ccccc1C2)CN(C)CC3)cccc4;
	InChI InChI=1S/C18H20N2/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19/h2-9,18H,10-13H2,1H3 ; Key:UEQUQVLFIPOEMF-UHFFFAOYSA-N ;
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Mianserin, sold under the brand name Tolvon among others, is an atypical antidepressant that is used primarily in the treatment of depression in Europe and elsewhere in the world.^[6] It is a tetracyclic antidepressant (TeCA). Mianserin is closely related to mirtazapine, both chemically and in terms of its actions and effects, although there are significant differences between the two drugs (for example, its higher noradrenergic activity and lower 5-HT3 receptor antagonism).^[7]

^ Cite error: The named reference IndexNominum2000 was invoked but never defined (see the help page).
^ Cite error: The named reference Drugs.com was invoked but never defined (see the help page).
^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
^ ^a ^b ^c ^d ^e Truven Health Analytics, Inc. Drugdex System (Internet) [cited 2013 Sep 29]. Greenwood Village, CO: Thomsen Healthcare; 2013.
^ Cite error: The named reference TOLVON was invoked but never defined (see the help page).
^ "Mianserin 30 mg film-coated tablets". UK Electronic Medicines Compendium. January 2014. Retrieved 20 August 2017.
^ Kelder J, Funke C, De Boer T, Delbressine L, Leysen D, Nickolson V (April 2011). "A Comparison of the Physicochemical and Biological Properties of Mirtazapine and Mianserin". Journal of Pharmacy and Pharmacology. 49 (4). Oxford University Press: 403–411. doi:10.1111/j.2042-7158.1997.tb06814.x. PMID 9232538. Retrieved 29 January 2022.

[IndexNominum2000-1] Cite error: The named reference IndexNominum2000 was invoked but never defined (see the help page).

[Drugs.com-2] Cite error: The named reference Drugs.com was invoked but never defined (see the help page).

[3] Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.

[DD-4] Truven Health Analytics, Inc. Drugdex System (Internet) [cited 2013 Sep 29]. Greenwood Village, CO: Thomsen Healthcare; 2013.

[TOLVON-5] Cite error: The named reference TOLVON was invoked but never defined (see the help page).

[UKlabel-6] "Mianserin 30 mg film-coated tablets". UK Electronic Medicines Compendium. January 2014. Retrieved 20 August 2017.

[MirtazDiff-7] Kelder J, Funke C, De Boer T, Delbressine L, Leysen D, Nickolson V (April 2011). "A Comparison of the Physicochemical and Biological Properties of Mirtazapine and Mianserin". Journal of Pharmacy and Pharmacology. 49 (4). Oxford University Press: 403–411. doi:10.1111/j.2042-7158.1997.tb06814.x. PMID 9232538. Retrieved 29 January 2022.

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