Milroy's disease

Milroy's disease
Other namesMilroy disease, Nonne-Milroy-Meige syndrome, Hereditary lymphedema[1]
This condition is inherited in an autosomal dominant manner.
SpecialtyMedical genetics 

Milroy's disease (MD) is a familial disease characterized by lymphedema, commonly in the legs, caused by congenital abnormalities in the lymphatic system. Disruption of the normal drainage of lymph leads to fluid accumulation and hypertrophy of soft tissues.[2][3]

It was named by Sir William Osler for William Milroy, a Canadian physician, who described a case in 1892, though it was first described by Rudolf Virchow in 1863.[4][5]

  1. ^ Bolognia JL, Jorizzo JL, Rapini RP (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1. OCLC 1058487222.
  2. ^ James WD, Berger TG, Elston DM, Andrews GC, Odom RB (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. p. 849. ISBN 978-0-7216-2921-6. OCLC 937244604.
  3. ^ Strayer DL, Rubin R (2007). Rubin's Pathology: Clinicopathologic Foundations of Medicine (5th ed.). Hagerstwon, MD: Lippincott Williams & Wilkins. ISBN 978-0-7817-9516-6.
  4. ^ synd/1326 at Whonamedit?
  5. ^ Milroy WF (1892). "An undescribed variety of hereditary edema". New York Medical Journal. 56: 505–8.
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