Mivacurium chloride

Mivacurium chloride
Clinical data
Trade names	Mivacron
Other names	bis[3-[6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1H-isoquinolin-2-yl]propyl] oct-4-enedioate
AHFS/Drugs.com	International Drug Names
Routes of; administration	IV
ATC code	M03AC10 (WHO) ;
Legal status
Legal status	In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	100% (IV)
Metabolism	ester hydrolysis by plasma cholinesterases
Identifiers
	IUPAC name (1R,1'R)-2,2'-[[(4E)-1,8-dioxooct-4-ene-1,8-diyl]bis(oxypropane-3,1-diyl)]bis[6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinolinium];
CAS Number	106861-44-3 ;
PubChem CID	71316;
DrugBank	DB01226;
ChemSpider	4444536;
UNII	600ZG213C3;
KEGG	D00763;
ChEMBL	ChEMBL984 ;
CompTox Dashboard (EPA)	DTXSID6048333 ;
Chemical and physical data
Formula	C58H80N2O14+2
Molar mass	1029.278 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[N+]1(CCc2cc(c(cc2[C@H]1Cc3cc(c(c(c3)OC)OC)OC)OC)OC)CCCOC(=O)CC/C=C/CCC(=O)OCCC[N+]4(CCc5cc(c(cc5[C@H]4Cc6cc(c(c(c6)OC)OC)OC)OC)OC)C.[Cl-].[Cl-];
	InChI InChI=1S/C58H80N2O14.2ClH/c1-59(25-21-41-35-47(63-3)49(65-5)37-43(41)45(59)29-39-31-51(67-7)57(71-11)52(32-39)68-8)23-17-27-73-55(61)19-15-13-14-16-20-56(62)74-28-18-24-60(2)26-22-42-36-48(64-4)50(66-6)38-44(42)46(60)30-40-33-53(69-9)58(72-12)54(34-40)70-10;;/h13-14,31-38,45-46H,15-30H2,1-12H3;2*1H/q+2;;/p-2/b14-13+;;/t45-,46-,59?,60?;;/m1../s1; Key:WMSYWJSZGVOIJW-ONUALHDOSA-L;

Mivacurium chloride (formerly recognized as BW1090U81, BW B1090U or BW1090U) is a short-duration non-depolarizing neuromuscular-blocking drug^[1] or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs,^[2] used adjunctively in anesthesia to facilitate endotracheal intubation^[3] and to provide skeletal muscle relaxation during surgery or mechanical ventilation.

^ Ihmsen H, Schmidt J, Schwilden H, Schmitt HJ, Muenster T (May 2009). "Influence of disease progression on the neuromuscular blocking effect of mivacurium in children and adolescents with Duchenne muscular dystrophy". Anesthesiology. 110 (5): 1016–1019. doi:10.1097/ALN.0b013e31819daf31. PMID 19352159.
^ Stout RG, Shine TS, Silverman DG, Brull SJ (September 2004). "Recovery of neuromuscular function after a combination of mivacurium and rocuronium". The Yale Journal of Biology and Medicine. 77 (5–6): 149–154. PMC 2259125. PMID 15989744.
^ Dempsey EM, Al Hazzani F, Faucher D, Barrington KJ (July 2006). "Facilitation of neonatal endotracheal intubation with mivacurium and fentanyl in the neonatal intensive care unit". Archives of Disease in Childhood. Fetal and Neonatal Edition. 91 (4): F279 – F282. doi:10.1136/adc.2005.087213. PMC 2672731. PMID 16464937.