Moxetumomab pasudotox
| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Mouse |
| Target | CD22 |
| Clinical data | |
| Trade names | Lumoxiti |
| Other names | moxetumomab pasudotox-tdfk, CAT-8015 |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a618052 |
| License data | |
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| Routes of administration | Intravenous |
| ATC code | |
| Legal status | |
| Legal status | |
| Identifiers | |
| CAS Number | |
| DrugBank | |
| ChemSpider |
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| UNII | |
| KEGG | |
| Chemical and physical data | |
| Formula | C2804H4339N783O870S14 |
| Molar mass | 63388.01 g·mol−1 |
| (what is this?) (verify) | |
Moxetumomab pasudotox, sold under the brand name Lumoxiti, is an anti-CD22 immunotoxin medication for the treatment of adults with relapsed or refractory hairy cell leukemia (HCL) who have received at least two prior systemic therapies, including treatment with a purine nucleoside analog.[2][3][4] Moxetumomab pasudotox is a CD22-directed cytotoxin and is the first of this type of treatment for adults with HCL.[4] The drug consists of the binding fragment (Fv) of an anti-CD22 antibody fused to a toxin called PE38.[5] This toxin is a 38 kDa fragment of Pseudomonas exotoxin A.
Hairy cell leukemia (HCL) is a rare, slow-growing cancer of the blood in which the bone marrow makes too many B cells (lymphocytes), a type of white blood cell that fights infection.[4] HCL is named after these extra B cells which look “hairy” when viewed under a microscope.[4] As the number of leukemia cells increases, fewer healthy white blood cells, red blood cells and platelets are produced.[4]
- ^ "Moxetumomab pasudotox (Lumoxiti) Use During Pregnancy". Drugs.com. 22 October 2018. Retrieved 20 April 2020.
- ^ a b Cite error: The named reference
Lumoxiti FDA labelwas invoked but never defined (see the help page). - ^ a b Cite error: The named reference
Lumoxiti EPARwas invoked but never defined (see the help page). - ^ a b c d e Cite error: The named reference
FDA PRwas invoked but never defined (see the help page). - ^ Kreitman RJ, Pastan I (October 2011). "Antibody fusion proteins: anti-CD22 recombinant immunotoxin moxetumomab pasudotox". Clinical Cancer Research. 17 (20): 6398–405. doi:10.1158/1078-0432.CCR-11-0487. PMC 3201735. PMID 22003067.