Muir–Torre syndrome

Muir–Torre syndrome
Other namesMTS
Micrograph of a sebaceous adenoma, as may be seen in Muir–Torre syndrome. H&E stain.
SpecialtyOncology, dermatology, medical genetics 

Muir–Torre syndrome is a rare hereditary, autosomal dominant cancer syndrome[1]: 663  that is thought to be a subtype of HNPCC (Lynch syndrome). Individuals are prone to develop cancers of the colon, genitourinary tract, and skin lesions, such as keratoacanthomas and sebaceous tumors. The genes affected are MLH1,[2] MSH2,[3] and more recently, MSH6,[4] and are involved in DNA mismatch repair.

  1. ^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 978-0-7216-2921-6.
  2. ^ "MLH1 mutL homolog 1 [Homo sapiens (Human)] - Gene - NCBI".
  3. ^ "MSH2 mutS homolog 2 [Homo sapiens (Human)] - Gene - NCBI".
  4. ^ "MSH6 mutS homolog 6 [Homo sapiens (Human)] - Gene - NCBI".
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