Neonatal lupus erythematosus

Neonatal lupus erythematosus
SpecialtyNeonatology, Immunology

Neonatal lupus erythematosus is an autoimmune disease in an infant born to a mother with anti-Ro/SSA and with or without anti-La/SSB antibodies.[1][2] The disease most commonly presents with a diffuse/periorbital rash resembling subacute cutaneous lupus erythematosus and can have systemic abnormalities such as complete heart block or hepatosplenomegaly.[3] Neonatal lupus is usually benign and self-limited.[3] Many of the clinical manifestations are transient, but certain heart problems can be permanent.[4] Diagnosis is based on maternal antibodies and clinical manifestations.[1] Treatment and management is mainly supportive and focused on preventing complete heart block if possible.[5]

  1. ^ a b Cite error: The named reference :1 was invoked but never defined (see the help page).
  2. ^ Cite error: The named reference Wallace19 was invoked but never defined (see the help page).
  3. ^ a b Hon KL, Leung AK (2012). "Neonatal lupus erythematosus". Autoimmune Diseases. 2012: 301274. doi:10.1155/2012/301274. PMC 3437607. PMID 22973504.
  4. ^ Cite error: The named reference Tsokos20 was invoked but never defined (see the help page).
  5. ^ Cite error: The named reference :3 was invoked but never defined (see the help page).
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