Nissl body

In cellular neuroscience, Nissl bodies (also called Nissl granules, Nissl substance or tigroid substance) are discrete granular structures in neurons that consist of rough endoplasmic reticulum, a collection of parallel, membrane-bound cisternae studded with ribosomes on the cytosolic surface of the membranes.[1] Nissl bodies were named after Franz Nissl, a German neuropathologist who invented the staining method bearing his name (Nissl staining).[2][3] The term "Nissl bodies" generally refers to discrete clumps of rough endoplasmic reticulum and free ribosomes in nerve cells. Masses of rough endoplasmic reticulum also occur in some non-neuronal cells, where they are referred to as ergastoplasm, basophilic bodies,[1] or chromophilic substance.[4] While these organelles differ in some ways from Nissl bodies in neurons,[5] large amounts of rough endoplasmic reticulum are generally linked to the copious production of proteins.[1]

  1. ^ a b c Junqueira LC, Carniero J, Kelley RO (1995). Basic Histology. Appleton & Lange. ISBN 0-8385-0567-8.
  2. ^ Richard H. Thompson (29 March 2000). The Brain: A Neuroscience Primer. Macmillan. pp. 35–. ISBN 978-0-7167-3226-6. Retrieved 4 January 2013.
  3. ^ Da Mota Gomes M (2019). "Franz Nissl (1860-1919), noted neuropsychiatrist and neuropathologist, staining the neuron, but not limiting it". Dementia & Neuropsychologia. 13 (3): 352–355. doi:10.1590/1980-57642018dn13-030014. PMC 6753910.
  4. ^ Fawcett, Don W. (1966). The Cell: Its Organelles and Inclusions. W.B. Saunders Company. ISBN 0-7216-3585-7.
  5. ^ Peters A, Palay SL, Webster Hd (1991). The Fine Structure of the Nervous System. Oxford University Press. ISBN 0-19-506571-9.
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