Norepinephrine releasing agent

A norepinephrine releasing agent (NRA), also known as an adrenergic releasing agent, is a catecholaminergic type of drug that induces the release of norepinephrine (noradrenaline) and epinephrine (adrenaline) from the pre-synaptic neuron into the synapse.[1][2] This in turn leads to increased extracellular concentrations of norepinephrine and epinephrine therefore an increase in adrenergic neurotransmission.[1][2][3][4]

A closely related type of drug is a norepinephrine reuptake inhibitor (NRI), for instance reboxetine.[5][6] Another class of drugs that stimulates adrenergic activity is the adrenergic receptor agonist class.[7]

  1. ^ a b Rothman RB, Baumann MH (October 2003). "Monoamine transporters and psychostimulant drugs". European Journal of Pharmacology. 479 (1–3): 23–40. doi:10.1016/j.ejphar.2003.08.054. PMID 14612135.
  2. ^ a b Rothman RB, Baumann MH (2006). "Therapeutic potential of monoamine transporter substrates". Current Topics in Medicinal Chemistry. 6 (17): 1845–1859. doi:10.2174/156802606778249766. PMID 17017961.
  3. ^ Parker K, Brunton L, Goodman LS, Lazo JS, Gilman A (2006). Goodman & Gilman's The Pharmacological Basis of Therapeutics (11 ed.). New York: McGraw-Hill. ISBN 0-07-142280-3. Archived from the original on 2011-11-18. Retrieved 2011-06-26.
  4. ^ Foye W, Lemke T, Williams D (2008). Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. ISBN 978-0-7817-6879-5. Retrieved 7 December 2024.
  5. ^ N Maiti S, P Kamalesh Babu R (2006). "Norepinephrine Reuptake Inhibitors for Depression, ADHD and Other Neuropsychiatric Disorders". Heterocycles. 69 (1): 539. doi:10.3987/REV-06-SR(O)1. ISSN 0385-5414.
  6. ^ Liu S, Molino BF (2007). "Chapter 2 Recent Developments in Monoamine Reuptake Inhibitors". Annual Reports in Medicinal Chemistry. Vol. 42. Elsevier. pp. 13–26. doi:10.1016/s0065-7743(07)42002-4. ISBN 978-0-12-373912-4.
  7. ^ Stanford SC, Heal DJ (2019). "Catecholamines: Knowledge and understanding in the 1960s, now, and in the future". Brain Neurosci Adv. 3: 2398212818810682. doi:10.1177/2398212818810682. PMC 7058270. PMID 32166174.
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