Optic nerve glioma
| Optic nerve glioma | |
|---|---|
| Magnetic resonance image of a large retrobulbar optic nerve tumor causing massive proptosis | |
| Specialty | Oncology |
Optic nerve glioma (or optic glioma), a form of glioma which affects the optic nerve, is often one of the central nervous system manifestations of neurofibromatosis 1.[1][2]
Optic gliomas are usually pilocytic tumors, and can involve the optic nerve or optic chiasm.[3] Optic gliomas are usually associated with neurofibromatosis type 1 in 30% of people with the condition.[3]
Optic nerve gliomas have low mortality but extremely high prevalence of vision loss and eye-bulging exophthalmos) in children.[4] As of 2014, approximately 1000 cases had been reported.[4]
- ^ Huson, Susan Mary; Hughes, Richard Anthony Cranmer (1994). The neurofibromatoses: a pathogenetic and clinical overview. London: Chapman & Hall. 1.3.2:9. ISBN 0-412-38920-7.
- ^ Skelley, Tao Le, Vikas Bhushan, Nathan William (2012-03-12). First aid for the USMLE step 2 CK (8th ed.). New York: McGraw-Hill Medical. ISBN 978-0-07-176137-6.
{{cite book}}: CS1 maint: multiple names: authors list (link) - ^ a b Goldman, Lee. Goldman's Cecil Medicine (24th ed.). Philadelphia: Elsevier Saunders. p. 1251. ISBN 1437727883.
- ^ a b Cameron, JD; Rodriguez, FJ; Rushing, E; Horkayne-Szakaly, I; Eberhart, C (2014). "An 80-year experience with optic nerve glioma cases at the Armed Forces Institute of Pathology: evolution from museum to molecular evaluation suggests possibe interventions in the cellular senescence and microglial pathways (an American Ophthalmological Society thesis)". Transactions of the American Ophthalmological Society. 112: 11–25. PMC 4234453. PMID 25411512.