Oxitriptan
| Clinical data | |
|---|---|
| Trade names | Cincofarm, Levothym, Levotonine, Oxyfan, Serovit, Telesol, Trimag, Tript-OH, Triptum[1] |
| Other names | Oxytryptan; 5-Hydroxytryptophan; L-5-Hydroxytryptophan; 5-Hydroxy-L-tryptophan; L-5-HTP; 5-HTP; α-Carboxy-5-hydroxytryptamine; α-Carboxy-5-HT |
| Routes of administration | Oral[1] |
| Drug class | Serotonin precursor; Serotonin receptor agonist |
| ATC code | |
| Pharmacokinetic data | |
| Bioavailability | 49 ± 19%[1] With carbidopa: up to 84%[1] |
| Metabolism | Decarboxylation |
| Metabolites | • Serotonin |
| Elimination half-life | Oral: 4.4–7 hours[1] IV: 2.2–7.4 hours[1] |
| Identifiers | |
IUPAC name
| |
| CAS Number | |
| PubChem CID | |
| IUPHAR/BPS | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEBI | |
| ChEMBL | |
| Chemical and physical data | |
| Formula | C11H12N2O3 |
| Molar mass | 220.228 g·mol−1 |
| 3D model (JSmol) | |
SMILES
| |
InChI
| |
Oxitriptan, also known as L-5-hydroxytryptophan (5-HTP) and sold under various brand names, is a medication and over-the-counter dietary supplement used in the treatment of depression and for other indications.[2][1][3][4] It is taken by mouth.[1]
Side effects of oxitriptan include appetite loss, nausea, diarrhea, vomiting, and serotonin syndrome.[1][2][3] The drug is a centrally permeable monoamine precursor and prodrug of serotonin and hence acts as a serotonin receptor agonist.[2] Chemically, oxitriptan is an amino acid and a tryptamine.[5]
Oxitriptan has been used clinically since at least the 1970s.[1]
- ^ a b c d e f g h i j Bowers K, Johns Cupp M, Tracy TS (2003). "5-Hydroxytryptophan (5-Hydroxy-l-Tryptophan, l-5-Hydroxytryptophan, Oxitriptan)". In Johns Cupp M, Tracy TS (eds.). Dietary Supplements: Toxicology and Clinical Pharmacology. Forensic Science and Medicine. Totowa, NJ: Humana. pp. 267–275. doi:10.1007/978-1-59259-303-3_16. ISBN 978-1-58829-014-4.
- ^ a b c Maffei ME (December 2020). "5-Hydroxytryptophan (5-HTP): Natural Occurrence, Analysis, Biosynthesis, Biotechnology, Physiology and Toxicology". Int J Mol Sci. 22 (1): 181. doi:10.3390/ijms22010181. PMC 7796270. PMID 33375373.
- ^ a b Turner EH, Loftis JM, Blackwell AD (March 2006). "Serotonin a la carte: supplementation with the serotonin precursor 5-hydroxytryptophan". Pharmacol Ther. 109 (3): 325–338. doi:10.1016/j.pharmthera.2005.06.004. PMID 16023217.
- ^ "Oxitriptan: Uses, Interactions, Mechanism of Action". DrugBank Online. 13 June 2005. Retrieved 30 September 2024.
- ^ "Oxitriptan". PubChem. Retrieved 30 September 2024.