Papez circuit

Papez circuit
The structures of the Papez circuit in the brain form a curved shape around the brainstem
Anatomical terminology


The Papez circuit /ppz/,[1][2][3] or medial limbic circuit, is a neural circuit for the control of emotional expression. In 1937, James Papez proposed that the circuit connecting the hypothalamus to the limbic lobe was the basis for emotional experiences. Paul D. MacLean reconceptualized Papez's proposal and coined the term limbic system. MacLean redefined the circuit as the "visceral brain" which consisted of the limbic lobe and its major connections in the forebrainhypothalamus, amygdala, and septum. Over time, the concept of a forebrain circuit for the control of emotional expression has been modified to include the prefrontal cortex.

  1. ^ MacLean, Paul D. (February 1–2, 1981). "James W. Papez Oral History Collection" (Interview: Audio). Interviewed by Kenneth E. Livingston. Archived from the original on September 22, 2015. Retrieved October 24, 2016.
  2. ^ Greenberg, Stephen (October 24, 2016). "Pronunciation of James W. Papez according to Oral History Tapes housed in U.S. National Library of Medicine" (Interview: Telephone Conversation). Interviewed by James W. H. Sonne.
  3. ^ Livingston, Kenneth E. James W. Papez Oral History Collection. U.S. National Library of Medicine, 1981